Phenotypic and molecular identification of Coccidioides posadasii in a patient evaluated for bilateral lung transplantation
| Autor: | Gabriela Lopez-Daneri, Fernanda Landaburu, A Fernández, P. giorgio, C. Nagel, María Teresa Mujica, C. Iovannitti, M Tokumoto |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Coccidioidomycosis biology Coccidioides Lung Diseases Fungal Coccidioides immitis medicine.medical_treatment Bilateral lung transplantation biology.organism_classification medicine.disease Microbiology Phenotype Organ transplantation Coccidioides posadasii Pneumonia Infectious Diseases Amphotericin B deoxycholate Immunology medicine Lung transplantation Humans Female Lung Transplantation |
| Zdroj: | Revista iberoamericana de micologia. 29(4) |
| ISSN: | 2173-9188 |
| Popis: | Background Coccidioidomycosis is an endemic fungal infection caused by Coccidioides immitis and Coccidioides posadasii. It can be particularly severe in transplant recipients that have a current or a previous coccidioidal infection. Fatal case of coccidioidomycosis has been described in this group of patients. Aims We report a severe case of pneumonia caused by C. posadassi in a 29 year-old white woman that had been admitted to hospital as part of the evaluation for bilateral lung transplantation. The patient was a native and resident of Catamarca, Argentina. Molecular methodologies contributed to the species identification. Methods Clinical, laboratory records and microbiological tests were carried out to diagnose the infection and to identify C. posadasii. Results A fungus was isolated from BAL culture. Phenotypic characterization, specific PCR and experimental animal inoculation demonstrated the presence of C. posadasii. The patient responded well to amphotericin B deoxycholate. Lung transplantation was postponed. Conclusions Specific PCR can be an important alternative for the correct identification of C. immitis or C. posadasii in laboratories with implemented molecular biology tools. This case emphasizes the need for a systematic assessment in organ transplant units of patients inhabiting endemic areas of coccidioidomycosis. |
| Databáze: | OpenAIRE |
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