Exploratory Study of Predicted Indirectly ReCognizable HLA Epitopes in Mismatched Hematopoietic Cell Transplantations
| Autor: | Geneugelijk, Kirsten, Thus, Kirsten A., Van Deutekom, Hanneke W.M., Calis, Jorg J.A., Borst, Eric, Keşmir, Can, Oudshoorn, Machteld, Van Der Holt, Bronno, Meijer, Ellen, Zeerleder, Sacha, De Groot, Marco R., Von Dem Borne, Peter A., Schaap, Nicolaas, Cornelissen, Jan, Kuball, Jürgen, Spierings, Eric, Sub Theoretical Biology & Bioinformatics, Sub Theoretical Biology, Theoretical Biology and Bioinformatics |
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| Přispěvatelé: | AII - Inflammatory diseases, Hematology, CCA - Cancer biology and immunology, Sub Theoretical Biology & Bioinformatics, Sub Theoretical Biology, Theoretical Biology and Bioinformatics, Clinical Haematology, ACS - Pulmonary hypertension & thrombosis, Faculteit Medische Wetenschappen/UMCG |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Oncology HLA mismatch Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] Disease Epitope Epitopes MOLECULES 0302 clinical medicine HLA Antigens VERSUS-HOST-DISEASE Immunology and Allergy Child Original Research UNRELATED-DONOR biology Non-permissible mismatch Hematopoietic Stem Cell Transplantation HSCT-hematopoietic stem cell transplant Middle Aged HLA HLA-DPB1 HISTOCHECK Child Preschool PIRCHE Cohort Female DETERMINES NONPERMISSIVE MISMATCHES Antibody Unrelated Donors Adult lcsh:Immunologic diseases. Allergy medicine.medical_specialty HSCT—hematopoietic stem cell transplant Adolescent Immunology Human leukocyte antigen ACUTE GVHD Young Adult 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center Transplantation Immunology Internal medicine medicine Journal Article Humans Aged Proportional Hazards Models business.industry Infant CLASS-I MISMATCHES HLA Mismatch Transplantation 030104 developmental biology ANTIBODIES biology.protein lcsh:RC581-607 business RECIPIENT 030215 immunology |
| Zdroj: | Frontiers in Immunology, 10 Frontiers in Immunology, 10. Frontiers Media S. A. Frontiers in Immunology, 10(APR):880 Frontiers in Immunology, 10. Frontiers Media S.A. Frontiers in Immunology, 10. FRONTIERS MEDIA SA Geneugelijk, K, Thus, K A, van Deutekom, H W M, Calis, J J A, Borst, E, Keşmir, C, Oudshoorn, M, van der Holt, B, Meijer, E, Zeerleder, S, de Groot, M R, von dem Borne, P A, Schaap, N, Cornelissen, J, Kuball, J R & Spierings, E 2019, ' Exploratory Study of Predicted Indirectly ReCognizable HLA Epitopes in Mismatched Hematopoietic Cell Transplantations ', Frontiers in Immunology, vol. 10, no. APR, 880, pp. 880 . https://doi.org/10.3389/fimmu.2019.00880 Frontiers in Immunology, 10:880. Frontiers Media S.A. Frontiers in immunology, 10. Frontiers Media S.A. Frontiers in Immunology, Vol 10 (2019) Frontiers in Immunology Frontiers in Immunology, 10:880. Frontiers Media SA |
| ISSN: | 1664-3224 |
| Popis: | HLA-mismatches in hematopoietic stem-cell transplantation are associated with an impaired overall survival (OS). The aim of this study is to explore whether the Predicted Indirectly ReCognizable HLA-Epitopes (PIRCHE) algorithm can be used to identify HLA-mismatches that are related to an impaired transplant outcome. PIRCHE are computationally predicted peptides derived from the patient's mismatched-HLA molecules that can be presented by donor-patient shared HLA. We retrospectively scored PIRCHE numbers either presented on HLA class-I (PIRCHE-I) or class-II (PIRCHE-II) for a Dutch multicenter cohort of 103 patients who received a single HLA-mismatched (9/10) unrelated donor transplant in an early phase of their disease. These patients were divided into low and high PIRCHE-I and PIRCHE-II groups, based on their PIRCHE scores, and compared using multivariate statistical analysis methods. The high PIRCHE-II group had a significantly impaired OS compared to the low PIRCHE-II group and the 10/10 reference group (HR: 1.86, 95%-CI: 1.02-3.40; and HR: 2.65, 95%-CI: 1.53-4.60, respectively). Overall, PIRCHE-II seem to have a more prominent effect on OS than PIRCHE- I. This impaired OS is probably due to an increased risk for severe acute graft-vs.-host disease. These data suggest that high PIRCHE-II scores may be used to identify non-permissible HLA mismatches within single HLA-mismatched hematopoietic stem-cell transplantations. |
| Databáze: | OpenAIRE |
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