Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers
| Autor: | Eero Pukkala, Jennifer R. Harris, Axel Skytthe, Lorelei A. Mucci, Niels V. Holm, Hans-Olov Adami, Jaakko Kaprio, Kamila Czene, Thomas Sevenius Nilsen, Jacob v. B. Hjelmborg, Kaare Christensen |
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| Přispěvatelé: | Institute for Molecular Medicine Finland, Department of Public Health, University of Helsinki, Genetic Epidemiology |
| Rok vydání: | 2019 |
| Předmět: |
Male
cancer incidence Denmark ZYGOSITY Twins 0302 clinical medicine Risk Factors Neoplasms PROGRAM Medicine 030212 general & internal medicine Genetics (clinical) Finland education.field_of_study HERITABILITY Norway Incidence (epidemiology) Mortality rate Obstetrics and Gynecology Middle Aged 3142 Public health care science environmental and occupational health 3. Good health Health Records Personal 030220 oncology & carcinogenesis Cohort Colonic Neoplasms Female Cohort study Adult Adolescent Population 3122 Cancers selection NORWEGIAN-INSTITUTE DIAGNOSIS 03 medical and health sciences QUALITY-CONTROL Testicular Neoplasms COMPLETENESS cohort study Diseases in Twins Humans VALIDITY education Aged Sweden SELECTION BIAS business.industry Cancer Heritability medicine.disease Zygosity REGISTRY Pediatrics Perinatology and Child Health record linkage business Demography |
| Zdroj: | Twin Research and Human Genetics Skytthe, A, Harris, J R, Czene, K, Mucci, L, Adami, H-O, Christensen, K, Hjelmborg, J, Holm, N V, Nilsen, T S, Kaprio, J & Pukkala, E 2019, ' Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers ', Twin Research and Human Genetics, vol. 22, no. 2, pp. 99-107 . https://doi.org/10.1017/thg.2019.10 |
| ISSN: | 1832-4274 |
| DOI: | 10.1017/thg.2019.10 |
| Popis: | The Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95% confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95% [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95% CI [0.96, 0.99]) in men and 0.96 (95% CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95% CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95% CI [0.76, 0.89]), lung (SIR 0.89; 95% CI [0.85, 0.92]) and colon (SIR 0.90; 95% CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations. The Nordic countries have comprehensive, population-based health and medical registries linkable on individually unique personal identity codes, enabling complete long-term follow-up. The aims of this study were to describe the NorTwinCan cohort established in 2010 and assess whether the cancer mortality and incidence rates among Nordic twins are similar to those in the general population. We analyzed approximately 260,000 same-sexed twins in the nationwide twin registers in Denmark, Finland, Norway and Sweden. Cancer incidence was determined using follow-up through the national cancer registries. We estimated standardized incidence (SIR) and mortality (SMR) ratios with 95% confidence intervals (CI) across country, age, period, follow-up time, sex and zygosity. More than 30,000 malignant neoplasms have occurred among the twins through 2010. Mortality rates among twins were slightly lower than in the general population (SMR 0.96; CI 95% [0.95, 0.97]), but this depends on information about zygosity. Twins have slightly lower cancer incidence rates than the general population, with SIRs of 0.97 (95% CI [0.96, 0.99]) in men and 0.96 (95% CI [0.94, 0.97]) in women. Testicular cancer occurs more often among male twins than singletons (SIR 1.15; 95% CI [1.02, 1.30]), while cancers of the kidney (SIR 0.82; 95% CI [0.76, 0.89]), lung (SIR 0.89; 95% CI [0.85, 0.92]) and colon (SIR 0.90; 95% CI [0.87, 0.94]) occur less often in twins than in the background population. Our findings indicate that the risk of cancer among twins is so similar to the general population that cancer risk factors and estimates of heritability derived from the Nordic twin registers are generalizable to the background populations. |
| Databáze: | OpenAIRE |
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