Comprehensive mapping of immune perturbations associated with severe COVID-19
| Autor: | Laura A. Vella, Madison E. Weirick, Ajinkya Pattekar, Luanne Bershaw, Ariel R. Weisman, Claudia P. Arevalo, Michael R. Betts, Nicholas Han, Leticia Kuri-Cervantes, Marcus J. Bolton, Divij Mathew, Sigrid Gouma, Eline T. Luning Prak, Scott E. Hensley, Wenzhao Meng, Caroline A. G. Ittner, Justin Kim, Eileen C. Goodwin, Allison R. Greenplate, Jeanette Dougherty, E. John Wherry, Amy E. Baxter, Tiffanie K. Jones, Oliva Kuthuru, Aaron M. Rosenfeld, Nuala J. Meyer, R.S. Agyekum, Nilam S. Mangalmurti, M. Betina Pampena, Elizabeth M. Anderson, Sokratis A. Apostolidis |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Coronavirus disease 2019 (COVID-19) Neutrophils T-Lymphocytes T cell Pneumonia Viral Immunology B-Lymphocyte Subsets macromolecular substances Lymphocyte Activation Betacoronavirus 03 medical and health sciences 0302 clinical medicine Immune system Immunity Humans Medicine Lymphocyte Count Neutrophil to lymphocyte ratio Clonal Selection Antigen-Mediated Receptor Pandemics Research Articles Aged SARS-CoV-2 business.industry R-Articles COVID-19 General Medicine Middle Aged biochemical phenomena metabolism and nutrition medicine.disease Immunity Innate Coronavirus 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cytokines Female Coronavirus Infections business Immunologic Memory Pneumonia (non-human) Clonal selection |
| Zdroj: | Science Immunology |
| ISSN: | 2470-9468 |
| DOI: | 10.1126/sciimmunol.abd7114 |
| Popis: | Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. Profound plasmablast expansion, innate cell modulation, and T cell activation are defining features of severe COVID-19. |
| Databáze: | OpenAIRE |
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