β‐Site amyloid precursor protein–cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin‐related receptor with A‐type repeats, soluble amyloid precursor protein, and tau
| Autor: | Paolo Livrea, Hideaki Bujo, Robert Perneczky, Timo Grimmer, Meizi Jiang, Panagiotis Alexopoulos, Christine Westerteicher, Amalia Tsolakidou, Francesco Roselli, Maria Rosaria Leante, Alexander Kurz, Martina Kratzer, Liang-Hao Guo |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Psychometrics Epidemiology BACE1-AS tau Proteins Amyloid beta-Protein Precursor Cellular and Molecular Neuroscience Cerebrospinal fluid Developmental Neuroscience Alzheimer Disease Retrograde Degeneration mental disorders Amyloid precursor protein Aspartic Acid Endopeptidases Humans Receptor LDL-Receptor Related Proteins Aged Amyloid beta-Peptides biology Chemistry Health Policy P3 peptide Membrane Transport Proteins Middle Aged Peptide Fragments Biochemistry of Alzheimer's disease Psychiatry and Mental health Alpha secretase Biochemistry biology.protein Female Neurology (clinical) Amyloid Precursor Protein Secretases Geriatrics and Gerontology Amyloid precursor protein secretase Biomarkers |
| Zdroj: | Alzheimer's & Dementia. 9:386-391 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2012.01.015 |
| Popis: | Background β-Site amyloid precursor protein (APP)–cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer's disease (AD). Methods The present study explored the correlation between BACE1 activity and cerebrospinal fluid (CSF) markers of APP metabolism and axonal degeneration in 63 patients with mild AD and 12 healthy control subjects. Results In the AD group, positive correlations between BACE1 activity and soluble APP β, the APP sorting receptor sortilin-related receptor with A-type repeats (also known as SorLA or LR11), and tau were detected. BACE1 activity was not associated with amyloid β 1–42 or soluble APP α concentrations in the AD group, and no associations between BACE1 activity and any of the protein concentrations were found in the control group. Conclusion Our results confirm the relevance of BACE1 and sortilin-related receptor with A-type repeats within the amyloid cascade and also provide a further piece of evidence for the link between amyloid and tau pathology in AD. |
| Databáze: | OpenAIRE |
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