'Sex hormone independent associations between insulin resistance and thyroid status -a gender based biochemical study on clinically euthyroid non-obese, overweight and obese type 2 diabetics'

Autor: A R Srinivasan, Rajendran Jayanthi
Rok vydání: 2019
Předmět:
0301 basic medicine
Blood Glucose
Male
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Thyroid Gland
Overweight
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Sex hormone-binding globulin
Insulin
Euthyroid
Gonadal Steroid Hormones
biology
Anthropometry
General Medicine
Middle Aged
Prognosis
Female
medicine.symptom
Adult
medicine.medical_specialty
India
030209 endocrinology & metabolism
03 medical and health sciences
Insulin resistance
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Obesity
Aged
Glycated Hemoglobin
business.industry
Type 2 Diabetes Mellitus
medicine.disease
030104 developmental biology
Endocrinology
chemistry
Diabetes Mellitus
Type 2
Case-Control Studies
biology.protein
Glycated hemoglobin
Insulin Resistance
business
Body mass index
Biomarkers
Follow-Up Studies
Zdroj: Diabetesmetabolic syndrome. 13(3)
ISSN: 1878-0334
Popis: Aim Studies indicate that type 2 diabetes mellitus (T2DM) might contribute to the development of thyroid disorders (TD). However, few gender based reports are available describing therelationship between T2DM and TD in clinically euthyroid, anthropometry specified groups of type 2 diabetics. The aim of this study was to relategender based biochemical changes in anthropometry specified, clinically euthyroid type 2 diabetics. Methodology The study was carried out on clinically euthyroid type 2 diabetics (male n = 269; female n = 301) at a tertiary health care unit in Pondicherry, South India. Three groups were segregatedbased on Body mass Index: 153 non-obese type 2 diabetics (BMI = 18.5–24.99), 291 overweight type 2 diabetics (BMI = 25–29.99) and 126 obese type 2 diabetics (BMI ≥ 30). Biochemical parameters included glycated hemoglobin, insulin resistance, Cortisol and Thyroid profile. Results The study had included clinically euthyroid type 2 diabetics (52.8% females and 47.2% males). Statistically significant associationsweredifferently observed between insulin resistance (dependent variable) andother independent variables, irrespective of sex hormone status. Total protein was negatively related in non -obese male type 2 diabetics (R = 0.780); Triiodothyronine was inversely associated in overweight males, whereas cortisol and the divalent cations (Zinc and Magnesium) depicted positive association (R = 0.555) in the same group (overweight), butcortisol in non -obese female type 2 diabeticswas negative (R = 0.742); Glycated hemoglobin and calcium exhibited positive relationshipin obese type 2 female diabetics (R = 0.771).. Conclusion Our study has revealed distinctive relationship between T2DM and TD in the anthropometry specified, clinically euthyroid and gender based type 2 diabetics, independent of the sex hormones.
Databáze: OpenAIRE
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