Complete genome sequence of a coxsackievirus type A24 variant causing an outbreak of acute haemorrhagic conjunctivitis in southeastern Mexico in 2017
| Autor: | Fabiola Garcés-Ayala, Lucía Hernández-Rivas, David Esaú Fragoso-Fonseca, Edgar Mendieta-Condado, Noé Escobar-Escamilla, José Ernesto Ramírez-González, Elizabeth González-Durán, Irma López-Martínez, Fernando I. Puerto, Gisela Barrera-Badillo, José Alberto Díaz-Quiñonez, Abril Paulina Rodríguez-Maldonado |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Coxsackievirus Infections Genome Viral Coxsackievirus Genome Virus Disease Outbreaks 03 medical and health sciences Medical microbiology Virology Genotype medicine Humans Clade Mexico 030304 developmental biology Whole genome sequencing 0303 health sciences Base Sequence Whole Genome Sequencing biology 030306 microbiology Outbreak General Medicine biology.organism_classification Enterovirus C Human Conjunctivitis Acute Hemorrhagic |
| Zdroj: | Archives of Virology. 165:1015-1018 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | Cases of acute haemorrhagic conjunctivitis (AHC) caused by a coxsackie virus A24 variant (CV-A24v) in Mexico have been reported since 1987; however, no molecular data on the causative strains have been available. Here, we report the identification of the etiological agent responsible for the most recent AHC outbreak in southeastern Mexico (at the end of 2017) as well as the complete genome sequences of seven isolates, using next-generation sequencing (NGS). Phylogenomic analysis of the CV-A24v sequences reported here showed similarity to contemporary strains causing AHC outbreaks in French Guiana and Uganda, forming a novel clade related to genotype IV. Moreover, a specific mutational pattern in the non-structural proteins was identified in the 2017 isolates. This is the first report of genetic characterization of CV-A24v isolates obtained in Mexico. |
| Databáze: | OpenAIRE |
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