Is bone equally responsive to calcium and vitamin D intake from food vs. supplements? Use of 41calcium tracer kinetic model

Autor: Christine E. Richardson, Janet M Peerson, Elieke Demmer, Bruce A. Buchholz, Marta D. Van Loan, Tara S. Rogers, Marjorie G. Garrod, Darren J. Hillegonds, Erik R. Gertz
Rok vydání: 2016
Předmět:
Tracer kinetic
lcsh:Diseases of the musculoskeletal system
BMI
body mass index
Endocrinology
Diabetes and Metabolism
AI
adequate intake
NDSR
Nutrition Data System for Research
Dietary interventions
0302 clinical medicine
HCl
hydrochloric acid
Orthopedics and Sports Medicine
030212 general & internal medicine
PTH
parathyroid hormone
RCT
randomized controlled trial
ANOVA
analysis of variance
qCT
quantitative computed tomography
Kinetic model
41Ca
RDA
recommended dietary allowances
DXA
dual energy X-ray absorptiometry
Postmenopausal
Calcium supplement
AMS
accelerator mass spectrometry
BMI - Body mass index
BMC
bone mineral content
CTx
serum C terminal telopeptide of type 1 collagen
medicine.medical_specialty
BMD
bone mineral density
nCi
nanocurrie
chemistry.chemical_element
030209 endocrinology & metabolism
Calcium
NH4OH
ammonium hydroxide
Article
Bone resorption
Dairy
03 medical and health sciences
Internal medicine
medicine
Vitamin D and neurology
business.industry
41Ca
calcium-41
CV
coefficient of variation
BAP
bone specific alkaline phosphatase
Vitamin D intake
Endocrinology
chemistry
WHNRC
Western Human Nutrition Research Center
lcsh:RC925-935
business
ELISA
enzyme linked immune-sorbent assay
Zdroj: Bone Reports, Vol 5, Iss, Pp 117-123 (2016)
Bone Reports
ISSN: 2352-1872
DOI: 10.1016/j.bonr.2016.05.001
Popis: Background Few interventions directly compare equivalent calcium and vitamin D from dairy vs. supplements on the same bone outcomes. The radioisotope calcium-41 (41Ca) holds promise as a tracer method to directly measure changes in bone resorption with differing dietary interventions. Objective Using 41Ca tracer methodology, determine if 4 servings/day of dairy foods results in greater 41Ca retention than an equivalent amount of calcium and vitamin D from supplements. Secondary objective was to evaluate the time course for the change in 41Ca retention. Methods In this crossover trial, postmenopausal women (n = 12) were dosed orally with 100 nCi of 41Ca and after a 180 day equilibration period received dairy (4 servings/day of milk or yogurt; ~ 1300 mg calcium, 400 IU cholecalciferol (vitamin D3/day)) or supplement treatments (1200 mg calcium carbonate/day and 400 IU vitamin D3/day) in random order. Treatments lasted 6 weeks separated by a 6 week washout (WO). Calcium was extracted from weekly 24 h urine collections; accelerator mass spectrometry (AMS) was used to determine the 41/40Ca ratio. Primary outcome was change in 41/40Ca excretion. Secondary outcome was the time course for change in 41Ca excretion during intervention and WO periods. Results The 41/40Ca ratio decreased significantly over time during both treatments; there was no difference between treatments. Both treatments demonstrated a significant retention of 41Ca within 1–2 weeks (p = 0.0007 and p
Highlights • Investigated, using 41Ca tracer, whether bone response to calcium and vitamin D differed based on the source of nutrients, foods vs. supplements. • There was no difference in the bone response by treatment group. • Both dairy foods and supplements resulted in reduce 41Ca excretion in urine. • Reduction in 41Ca excretion occurred with 2 weeks of initiating the interventions. • Removal of interventions resulted in 41Ca excretion returning to pre-intervention levels
Databáze: OpenAIRE
Externí odkaz: