Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients

Autor: Edgardo Cristiano, Liliana Patrucco, Juan Ignacio Rojas, Georgina Murphy, Angel Golimstok, María C. Fernández, Jimena Miguez, Francisco Sánchez, J. Funes
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Thalamus
BRAIN VOLUME
Medicina Clínica
Neuropsychological Tests
Volume change
030218 nuclear medicine & medical imaging
Disability Evaluation
03 medical and health sciences
Multiple Sclerosis
Relapsing-Remitting
0302 clinical medicine
Internal medicine
Image Processing
Computer-Assisted
Humans
Medicine
Cognitive Dysfunction
Radiology
Nuclear Medicine and imaging
Prospective Studies
Cognitive impairment
MULTIPLE SCLEROSIS
business.industry
Multiple sclerosis
Neurología Clínica
Organ Size
General Medicine
COGNITIVE IMPAIRMENT
General Neuroimaging
medicine.disease
Logistic Models
Relapsing remitting
Brain size
Disease Progression
Cardiology
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
THALAMUS
Follow-Up Studies
Zdroj: The Neuroradiology Journal. 31:350-355
ISSN: 2385-1996
1971-4009
DOI: 10.1177/1971400918781977
Popis: Aims: The objective of the study was to assess whether changes in the volume of the thalamus during the onset of multiple sclerosis predict cognitive impairment after accounting for the effects of brain volume loss. Methods: A prospective study included patients with relapsing–remitting multiple sclerosis less than 3 years after disease onset (defined as the first demyelinating symptom), Expanded Disability Status Scale of 3 or less, no history of cognitive impairment and at least 2 years of follow-up. Patients were clinically followed up with annual brain magnetic resonance imaging and neuropsychological evaluations for 2 years. Measures of memory, information processing speed and executive function were evaluated at baseline and follow-up with a comprehensive neuropsychological test battery. After 2 years, the patients were classified into two groups, one with and the other without cognitive impairment. Brain dual-echo, high-resolution three-dimensional T1-weighted magnetic resonance imaging scans were acquired at baseline and every 12 months for 2 years. Between-group differences in thalamus volume, total and neocortical grey matter and white matter volumes were assessed using FIRST, SIENA, SIENAXr, FIRST software (logistic regression analysis P < 0.05 significant). Results: Sixty-one patients, mean age 38.4 years, 35 (57%) women were included. At 2 years of follow-up, 17 (28%) had cognitive impairment. Cognitive impairment patients exhibited significantly slower information processing speed and attentional deficits compared with patients without cognitive impairment (P < 0.001 and P = 0.02, respectively). In the cognitive impairment group a significant reduction in the percentage of thalamus volume (P < 0.001) was observed compared with the group without cognitive impairment. Conclusion: We observed a significant decrease in thalamus volume in multiple sclerosis-related cognitive impairment. Fil: Rojas, Juan Ignacio. Hospital Italiano; Argentina Fil: Murphy, Georgina. Hospital Italiano; Argentina Fil: Sánchez, Francisco. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Patrucco, Liliana. Hospital Italiano; Argentina Fil: Fernandez, Maria C.. Hospital Italiano; Argentina Fil: Miguez, Jimena. Hospital Italiano; Argentina Fil: Funes, Jorge. Hospital Italiano; Argentina Fil: Golimstok, Angel. Hospital Italiano; Argentina Fil: Cristiano, Edgardo. Hospital Italiano; Argentina
Databáze: OpenAIRE
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