Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model
| Autor: | Ahm H. M. Dur, Mj J. Hoekstra, Ali Pirayesh, Stan Monstrey, Rw W. Kreis, Cd D. Richters, Nj J. Paauw |
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| Přispěvatelé: | Molecular cell biology and Immunology, Division 6, CCA - Immuno-pathogenesis |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Acellular Dermis
Male medicine.medical_specialty Rat model Tissue Adhesions Abdominal wall Dermis Fibrosis Tensile Strength medicine Medicine and Health Sciences Animals Rats Wistar business.industry fungi Abdominal Wall food and beverages Abdominal wall repair Prostheses and Implants Surgical Mesh medicine.disease Biological materials Surgery Rats medicine.anatomical_structure business |
| Zdroj: | EUROPEAN SURGICAL RESEARCH Pirayesh, A, Dur, A H M, Paauw, N J, Monstrey, S, Kreis, R W, Hoekstra, MJ & Richters, C D 2008, ' Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model ', European Surgical Research, vol. 41, no. 4, pp. 346-352 . https://doi.org/10.1159/000161079 European Surgical Research, 41(4), 346-352. S. Karger AG |
| ISSN: | 0014-312X |
| DOI: | 10.1159/000161079 |
| Popis: | Background: Abdominal wall repair can be performed with synthetic or biological materials. Biological materials may reduce the risk of infections and fibrosis. The aim of this study was to evaluate two acellular human dermis products. Materials and Methods: A rat model was used to compare the two materials. One was prepared using low concentrations of NaOH; the other material was SureDerm™, which is commercially available. Full thickness defects were prepared in the abdominal wall and closed with the materials. Rats were sacrificed at 1 or 4 months after operation and the numbers of adhesions to the bowels were scored. Samples were tak- en for histological analysis and to measure the breaking strength. Results: In both groups a good functional integration of the implants with the abdominal wall was observed. There was no adhesion formation with the bowels in the group with the NaOH prototype. In the SureDerm group, 4 out of 7 rats showed only small adhesions at 4 months after operation. Breaking strength of the healed tissue was significantly higher in the NaOH prototype group at 4 months after operation (p < 0.0026). Conclusions: The results indicate that both human acellular dermis products may be used in clinical trials for closure of abdominal wall defects. |
| Databáze: | OpenAIRE |
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