Proximal muscle weakness as a result of osteomalacia associated with celiac disease: a case report
| Autor: | H. A. Gürgan, Bengi Ozoglu Oz, Hikmet Kocyigit, O. Akan |
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| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Proximal muscle weakness Endocrinology Diabetes and Metabolism Physical examination Gastroenterology Diagnosis Differential 03 medical and health sciences Young Adult 0302 clinical medicine Pregnancy Internal medicine medicine Back pain Humans 030203 arthritis & rheumatology Osteomalacia Muscle biopsy Muscle Weakness medicine.diagnostic_test business.industry nutritional and metabolic diseases Muscle weakness medicine.disease Rheumatology Surgery Pregnancy Complications Celiac Disease Female medicine.symptom Differential diagnosis business 030217 neurology & neurosurgery |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 27(2) |
| ISSN: | 1433-2965 |
| Popis: | A 24-year-old woman suffering from back and hip pain with difficulty in walking was reported. She had proximal muscle weakness. Laboratory findings led to the diagnosis of osteomalacia. Positivity of antibodies strengthened suspicion of celiac disease. In patients with proximal muscle weakness, osteomalacia should be considered in differential diagnosis even in a young woman. A 24-year-old woman suffering from back pain, bilateral hip pain, and difficulty in walking was reported. Her symptoms had started in the first trimester of pregnancy. In her physical examination, proximal muscle weakness and waddling gait pattern were determined. Her lumbar spine and hip MRI revealed no obvious pathological findings. Electromyography showed a myophatic pattern. Physical examination, normal values of creatine kinase, and muscle biopsy were supplied to exclude the diagnosis of primer muscle diseases. Laboratory findings led to the diagnosis of osteomalacia with normal renal function. Gastrointestinal symptoms and positivity of anti-gliadin and anti-endomysium antibodies strengthened the suspicion of celiac disease as a cause of the osteomalacia. The diagnosis of celiac disease was confirmed with duodenal mucosal biopsy. In patients with proximal muscle weakness and waddling gait pattern, osteomalacia should be considered in differential diagnosis even in a young woman and underlying disease should be investigated. |
| Databáze: | OpenAIRE |
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