Determinants of left ventricular mass in untreated mildly hypertensive subjects Hospitalet study in mild hypertension
| Autor: | Raquel Hernández del Rey, Pedro Armario, Jordi Juliá, Helios Pardell, Pilar Sánchez, Montserrat Martín-Baranera, Gerard Torres |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Megalencephalic leukoencephalopathy with subcortical cysts Ambulatory blood pressure Adolescent Urinary system Diastole Blood Pressure Hematocrit Body Mass Index Heart Rate Internal medicine Heart rate Internal Medicine medicine Humans symbols.heraldic_charge Aged medicine.diagnostic_test business.industry Cholesterol HDL Sodium Heart shape Middle Aged medicine.disease Surgery Blood pressure Echocardiography Hypertension symbols Cardiology Female Hypertrophy Left Ventricular business |
| Zdroj: | American Journal of Hypertension. 12:1084-1090 |
| ISSN: | 0895-7061 |
| DOI: | 10.1016/s0895-7061(99)00134-x |
| Popis: | The objectives of this cross-sectional study were to identify the determinants of left ventricular mass in untreated mildly hypertensive subjects at the Hypertension Unit, Department of Internal Medicine, Red Cross Hospital, Hospitalet de Llobregat, Barcelona, Spain. One hundred seventy-one untreated mildly hypertensive subjects, with a mean age of 41.1 ± 11.8 years (from 18 to 65 years) were sequentially visited in our Unit; 54% were men. Echocardiographic measurements of good quality were obtained in 142 subjects (83%). Two-dimensional guided M-mode echocardiograms were used and left ventricular mass was estimated according to the Penn convention. Left ventricular mass (LVM) was analyzed as a continuous variable. In the bivariate analysis, the variables that significantly correlated with LVM were patient’s height (r = 0.42, P < .0005), weight (r = 0.47, P ≤ .0005), heart rate (r = −0.22, P = .01), HDLc (r = −0.30, P = .002), hematocrit (r = −0.28, P = .001), urinary sodium excretion (r = 0.23, P = 0.012), and different measurements from the ambulatory blood pressure profile for 24 h. By means of multiple regression analysis, a maximum of 41.2% of LVM variability could be explained from the factors registered in our study. The final model included age, gender, patient’s weight, and diastolic night load from ambulatory blood pressure monitoring. When added to different models, weight and diastolic night load showed a similar strength in predicting left ventricular mass. In untreated patients with mild hypertension, traditional factors such as blood pressure levels explain a maximum of 41.2% of LVM variability. More knowledge is needed about factors that may alter cardiac morphology in the evolution of hypertensive patients. |
| Databáze: | OpenAIRE |
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