Loss of maternally derived human herpesvirus-6 immunity and natural infection in Argentinian infants
| Autor: | Lax A. Alessio, Silvia Medeot, Jorge Pavan, Dolores A. Bustos, Silvia Nates, Silvia E. Carricart, Héctor Gendelman |
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| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
Adult Male Adolescent medicine.medical_treatment Herpesvirus 6 Human Population Argentina Physiology Roseolovirus Infections Passive immunity Antibodies Viral Women in development HHV-6 Age Distribution Immunity Pregnancy Risk Factors antibody medicine Prevalence Humans Seroconversion education Fluorescent Antibody Technique Indirect education.field_of_study biology business.industry Infant General Medicine biology.organism_classification natural infection Clinical research Infectious Diseases Argentinian infants biology.protein Human herpesvirus 6 Female Antibody business Immunity Maternally-Acquired |
| Zdroj: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 5(4) |
| ISSN: | 1201-9712 |
| Popis: | Background: Human herpesvirus-6 (HHV-6) infection is widespread throughout the world. No data are available in Argentina about the loss of maternally derived HHV-6 immunity and natural infection in infants.Methods: A population of 100 pregnant women and 407 children between 1 and 15 months of age were assayed by indirect immunofluorescence to detect and quantify specific IgG anti-human herpesvirus-6 (anti-HHV-6) antibodies in Córdoba City, Argentina.Results: There was no significant difference in the positive rate between infants aged 1 to 9 months (range, 43.6–35.5%) and pregnant women (37%). Seropositive ratio dropped in the 10-month group (23.33% seropositive) and rose sharply in the 11-month group (38.89%), 12-month (60.61 %), and 13- to 15-month group (63.46%). The geometric mean titer (GMT) for infants in the 12 to 15 months age group (23.4–41.64) was significantly higher than the GMT for infants 10 months of age (11.04) (P < 0.05 with the Tukey-HSD test).Conclusions: This study shows a significant association between loss of passive HHV-6 antibody and age among infants. The results support evidence that HHV-6 enters the susceptible population at 11 months, leading to a high prevalence of antibodies in children between 13 and 15 months of age. |
| Databáze: | OpenAIRE |
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