Whole-body diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient mapping for staging patients with diffuse large B-cell lymphoma
| Autor: | Corinne Haioun, Michel Meignan, Alain Luciani, Emmanuel Itti, Chieh Lin, Eva Evangelista, Pauline Beaussart, Taoufik El-Gnaoui, Alexandre Vignaud, Karim Belhadj, Pierre Brugières, S. Lin, Alain Rahmouni |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Whole body imaging Sensitivity and Specificity hemic and lymphatic diseases Image Interpretation Computer-Assisted medicine Humans Effective diffusion coefficient Whole Body Imaging Radiology Nuclear Medicine and imaging Aged Neoplasm Staging Neuroradiology medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Middle Aged Image Enhancement medicine.disease Lymphoma Diffusion Magnetic Resonance Imaging Lymphoma Large B-Cell Diffuse Tomography Radiology Nuclear medicine business Diffuse large B-cell lymphoma Emission computed tomography Diffusion MRI |
| Zdroj: | European Radiology. 20:2027-2038 |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | To design a whole-body MR protocol using exclusively diffusion-weighted imaging (DWI) with respiratory gating and to assess its value for lesion detection and staging in patients with diffuse large B-cell lymphoma (DLBCL), with integrated FDG PET/CT as the reference standard.Fifteen patients underwent both whole-body DWI (b = 50, 400, 800 s/mm(2)) and PET/CT for pretreatment staging. Lymph node and organ involvement were evaluated by qualitative and quantitative image analysis, including measurement of the mean apparent diffusion coefficient (ADC).A total of 296 lymph node regions in the 15 patients were analysed. Based on International Working Group size criteria alone, DWI findings matched PET/CT findings in 277 regions (94%) (kappa score = 0.85, P0.0001), yielding sensitivity and specificity for DWI lymph node involvement detection of 90% and 94%. Combining visual ADC analysis with size measurement increased DWI specificity to 100% with 81% sensitivity. For organ involvement, the two techniques agreed in all 20 recorded organs (100%). All involved organ lesions showed restricted diffusion. Ann Arbor stages agreed in 14 (93%) of the 15 patients.Whole-body DWI with ADC analysis can potentially be used for lesion detection and staging in patients with DLBCL. |
| Databáze: | OpenAIRE |
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