A reference standard for plasma proteins is required for nutritional assessment of adult burn patients
| Autor: | M.M. Golstein, C. Badetti, V. Bernini, D. Bernard, G. Botti, J.C. Manelli |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Critical Care and Intensive Care Medicine Injury Severity Score Internal medicine medicine Humans Reference standards Retrospective Studies chemistry.chemical_classification biology Nutritional Support business.industry C-reactive protein Nutritional Requirements Albumin Acute-phase protein Blood Proteins General Medicine Middle Aged Reference Standards Blood proteins Retinol binding protein Transthyretin Nutrition Assessment Treatment Outcome Endocrinology chemistry Transferrin Emergency Medicine biology.protein Female Surgery Burns business Biomarkers Follow-Up Studies |
| Zdroj: | Burns. 24:337-345 |
| ISSN: | 0305-4179 |
| DOI: | 10.1016/s0305-4179(98)00031-x |
| Popis: | Plasma levels of visceral proteins (VP) are commonly used for evaluation of nutritional status. Low values observed in burn patients are caused by several factors including microvascular hyper-permeability and inflammatory processes. The aim of the study was to define a range of standard values specific to burn patients. Retrospective review: from days post-burn 12 to 43, four VP and three acute phase reactants (APR) were measured twice a week, in the plasma of 107 burn patients. From these data, standard' values were determined in respect with burn surface area (BSA) and post-burn time. The results were that the VP increase and APR decrease linearly during the study. Correlation between plasma proteins and BSA or post-burn day, change from protein to protein. Albumin and transferrin are less sensitive than prealbumin and especially retinol binding protein to variations of APR, but transferrin lacks of specificity. The conclusion of the study was that plasma levels of VP have to be compared to reference standard values. When levels lower than theoretical values are observed, simultaneous APR values (especially C reactive protein) have to be compared to their own reference standard, in order to separate nutritional from inflammatory effects. |
| Databáze: | OpenAIRE |
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