Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling
| Autor: | Zhi-Wei Gao, Cheng Wang, Xian Li, Linxiao Sun, Chenghao Shi, Yanyi Xiao, Min Weng, Yilong Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Aging Flavonols media_common.quotation_subject fisetin proliferation pancreatic cancer chemistry.chemical_compound Phosphatidylinositol 3-Kinases In vivo Cell Movement Pancreatic cancer Cell Line Tumor medicine PI3K/AKT/mTOR Humans Neoplasm Invasiveness Protein kinase B PI3K/AKT/mTOR pathway media_common Cell Proliferation business.industry TOR Serine-Threonine Kinases apoptosis Cell Biology medicine.disease In vitro Pancreatic Neoplasms chemistry Apoptosis Cancer research business Proto-Oncogene Proteins c-akt Fisetin Research Paper Signal Transduction |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Pancreatic cancer is an extremely malignant digestive tract tumor. With the increase of chemotherapeutic resistance of pancreatic cancer, clinical treatment is in a dilemma. Hence, it is pivotal to design an effective drug for treating individuals with pancreatic cancer. Fisetin extracted from vegetables, as well as fruits was explored to possess antioxidant, anti-cancer, anti-inflammatory along with anti-microbial properties. Nonetheless, there is limited research focusing on the utility of fisetin as an inhibitor of pancreatic cancer. Similarly, the mechanism through which Fisetin dampens pancreatic cancer remains unknown. This research work systematically evaluated the possible anti-cancer influences of fisetin in pancreatic cancer, as well as explored its responsible molecular mechanism. Our data revealed that fisetin obviously dampens pancreatic cancer progress in vitro along with in vivo dose-dependently. Furthermore, we established that fisetin repressed pancreatic cancer via explicitly targeting PI3K/AKT/mTOR signaling cascade and not the JAK2 cascade. Our data clarified that fisetin is a prospective anti-cancer drug for pancreatic cancer, as well as indicated the distinct molecular target of fisetin. |
| Databáze: | OpenAIRE |
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