Eyes with Suspicious Appearance of the Optic Disc and Normal Intraocular Pressure: Using Clinical and Epidemiological Characteristics to Differentiate Those with and without Glaucoma

Autor: Augusto Paranhos, Luis G. Biteli, Diego Torres Dias, Mauro T. Leite, Syril Dorairaj, Michele Ushida, Tiago S. Prata, Marina C. Sousa
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Intraocular pressure
Eye Diseases
genetic structures
Physiology
Sensory Physiology
Optic disk
lcsh:Medicine
Ocular hypertension
Glaucoma
Eye
0302 clinical medicine
Medicine and Health Sciences
Low Tension Glaucoma
lcsh:Science
Multidisciplinary
medicine.diagnostic_test
Middle Aged
medicine.anatomical_structure
Optic nerve
Female
Anatomy
Glaucoma
Open-Angle
Research Article
Optic disc
Adult
medicine.medical_specialty
Ocular Anatomy
Optic Disk
Optic Disc
Diagnosis
Differential
Ophthalmoscopy
03 medical and health sciences
Ocular System
Ophthalmology
medicine
Humans
Intraocular Pressure
Aged
business.industry
lcsh:R
Biology and Life Sciences
Health Risk Analysis
Optic Nerve
medicine.disease
eye diseases
Health Care
030104 developmental biology
030221 ophthalmology & optometry
Visual Field Tests
Eyes
Ocular Hypertension
lcsh:Q
sense organs
business
Head
Zdroj: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
PLoS ONE, Vol 11, Iss 7, p e0158983 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Federal University of Sao Paulo Among all glaucoma suspects, eyes with optic nerve head features suspicious or suggestive of early glaucoma are probably those that offer the greatest challenge for clinicians. In contrast with the robust longitudinal data published on ocular hypertension, there is no specific management guideline for these patients. Therefore, evaluating eyes with suspicious optic disc appearance and normal intraocular pressure (IOP), we sought to investigate potential differences in clinical and epidemiological characteristics to differentiate those with normaltension glaucoma (NTG) from those with presumed large physiological optic disc cups (pLPC). In this observational case-control study, we consecutively enrolled individuals with pLPC and NTG. All eyes had vertical cup-to-disc ratio (VCDR)>= 0.6 and untreated IOP= 30 months of follow-up with no evidence of glaucomatous neuropathy. Clinical and epidemiological parameters were compared between groups. Eighty-four individuals with pLPC and 40 NTG patients were included. Regarding our main results, NTG patients were significantly older and with a higher prevalence of Japanese descendants (p= 0.38). Significant odds ratios (OR) were found for race (OR = 2.42 for Japanese ancestry), age (OR = 1.05), VCDR (OR = 5.03), and disc size (OR = 0.04 p
Databáze: OpenAIRE
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