Radiotherapy of pituitary adenomas: state of the art
| Autor: | D. Pontvert, T. Khalil, B. Irthum, I. Tauveron, X. Zasadny, P. Verrelle, O. Gilliot |
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| Rok vydání: | 2007 |
| Předmět: |
Adenoma
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Radiosurgery Stereotactic radiotherapy Endocrinology Pituitary adenoma Humans Medicine Combined Modality Therapy Pituitary Neoplasms Survivors Survival analysis Medical treatment Brain Neoplasms Human Growth Hormone business.industry General Medicine medicine.disease Survival Analysis Prolactin Surgery Radiation therapy business Complication Follow-Up Studies |
| Zdroj: | Annales d'Endocrinologie. 68:337-348 |
| ISSN: | 0003-4266 |
| Popis: | Pituitary adenomas represent approximately 12% of intracranial tumors. They are defined as tumors that are functional or nonfunctional and invasive or noninvasive. Therapeutic strategies rely on surgery, medical treatment, and radiotherapy depending on histology. Neither the role of external radiotherapy nor the technique to be used are firmly established. Nonfunctioning adenomas must be operated on to relieve the compression. Prolactin-secreting adenomas are first treated with dopamine agonists, and GH-secreting adenomas are first treated by surgery if excising the complete tumor is possible; otherwise medical treatment is started. The first-line treatment of ACTH-secreting adenomas is surgery; however, in many cases, insufficient control of either secretion or tumoral volume leads to consideration of irradiation. Complications of conventional radiotherapy are well known and fractionated stereotactic radiotherapy appears to be as safe as radiosurgery. The volume to irradiate is still difficult to define, and this parameter can influence the technique chosen for treatment. Because the indications of radiotherapy are still debated, irradiation of pituitary adenomas must be decided by the complete team of endocrinologists, neurosurgeons, radiologists and radiotherapists. |
| Databáze: | OpenAIRE |
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