Protective Effect of Fucoxanthin Isolated from Laminaria japonica against Visible Light-Induced Retinal Damage Both in Vitro and in Vivo
| Autor: | Qingchou Chen, Le-Chang Sun, Yixiang Liu, Guang-Ming Liu, Xichun Zhang, Haixiu Chen, Meng Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine Lutein Light Xanthophylls Biology Protective Agents Retina Cell Line 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Retinal Diseases In vivo Vegetables Botany medicine Animals Humans Fucoxanthin chemistry.chemical_classification Retinal pigment epithelium Plant Extracts Retinal General Chemistry eye diseases Cell biology Zeaxanthin Oxidative Stress 030104 developmental biology medicine.anatomical_structure chemistry Xanthophyll 030221 ophthalmology & optometry Rabbits Laminaria Reactive Oxygen Species General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 64:416-424 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.5b05436 |
| Popis: | With increasingly serious eye exposure to light stresses, such as light-emitting diodes, computers, and widescreen mobile phones, efficient natural compounds for preventing visible light-induced retinal damages are becoming compelling needs in the modern society. Fucoxanthin, as the main light absorption system in marine algae, may possess an outstanding bioactivity in vision protection because of its filtration of blue light and excellent antioxidative activity. In this work, both in vitro and in vivo simulated visible light-induced retinal damage models were employed. The in vitro results revealed that fucoxanthin exhibited better bioactivities than lutein, zeaxanthin, and blueberry anthocyanins in inhibiting overexpression of vascular endothelial growth factor, resisting senescence, improving phagocytic function, and clearing intracellular reactive oxygen species in retinal pigment epithelium cells. The in vivo experiment also confirmed the superiority of fucoxanthin than lutein in protecting retina against photoinduced damage. This excellent bioactivity may be attributed to its unique structural features, including allenic, epoxide, and acetyl groups. Fucoxanthin is expected to be an important ocular nutrient in the future. |
| Databáze: | OpenAIRE |
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