Polymorphonuclear leukocyte-dependent modulation of platelet function: effect of cloricromene
| Autor: | Gianfranco Bazzoni, M. Prosdocimi, Aldo Del Maschio, Elisabetta Dejana, A. Zatta |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Platelets
Cytoplasm Cathepsin G Platelet aggregation Neutrophils In Vitro Techniques Pharmacology Biology Inhibitory postsynaptic potential Humans Platelet Polymorphonuclear leukocyte Serine Endopeptidases Cloricromene Chromonar hemic and immune systems Platelet Activation beta-Thromboglobulin Cathepsins In vitro Prostaglandin Endoperoxides Synthetic N-Formylmethionine Leucyl-Phenylalanine Cell culture 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Immunology Calcium Function (biology) |
| Zdroj: | European Journal of Pharmacology. 198:97-100 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(91)90568-b |
| Popis: | Cloricromene inhibits the activation of platelets and polymorphonuclear leukocytes (PMN) induced by specific stimuli. We report here that cloricromene caused a concentration-dependent reduction of platelet aggregation, β-thromboglobulin (β-TG) release and cytoplasmic Ca2+ movements induced by PMN stimulated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), and enhanced the inhibitory action of unstimulated PMN on platelet responses to the stable endoperoxide analog U46619. These effects may be of pharmacological interest in view of the multiple interactions between platelets and leukocytes that occur in thrombotic and inflammatory diseases. |
| Databáze: | OpenAIRE |
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