An immunogenetic view of delayed type hypersensitivity
| Autor: | R.R.P. de Vries |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pulmonary and Respiratory Medicine
biology Specific knowledge biology.organism_classification medicine.disease Epistemology Mycobacterium leprae Delayed hypersensitivity HLA Antigens Leprosy Immunology medicine Immune reactivity Humans Subunit vaccines Hypersensitivity Delayed Immunotherapy Robert koch |
| Zdroj: | Tubercle. 72(3) |
| ISSN: | 0041-3879 |
| Popis: | This review, the third in the series on cellular immune reactivity to tubercle bacilli in the centenary year of Koch's classical paper describing this phenomenon and its possible implications [1], represents an immunogenetic point of view. In fact this will be quite a broad point of view by an immunogeneticist who is not hampered by specific knowledge on therapy or prevention of tuberculosis. In this respect I probably do not differ very much from Robert Koch 100 years ago! An important difference, however, is that we think we now understand a great deal of the cellular and molecular basis of the immunological phenomena observed by Koch. Immunogenetics has contributed considerably to our current understanding and I will try to review that contribution here. Because thus far my main research interest has been in another mycobacterium, namely Mycobacterium leprae , I will use M. leprae and leprosy as an example to illustrate some ideas. The message of this review is that there is a reason for optimism: the knowledge recently gained by cellular and molecular immunologists as well as immunogeneticists has straightforward implications for the rational development of subunit vaccines and immunotherapeutic strategies. |
| Databáze: | OpenAIRE |
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