Impact of a twelve-year rotavirus vaccine program on acute diarrhea mortality and hospitalization in Brazil: 2006-2018
| Autor: | Carlos Dornels Freire de Souza, Victor Santana Santos, Luciane Moreno Storti-Melo, Myrela Conceição Santos de Jesus, Ricardo Queiroz Gurgel, Anna Klara Bohland, Ricardo Luiz Dantas Machado, Marcelo Vitor Costa Paes, Eitan Naaman Berezin, Ikaro Daniel de Carvalho Barreto, Pablo Amercio Silva Lima, Luis E. Cuevas |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Diarrhea Rotavirus Acute diarrhea Pediatrics medicine.medical_specialty Vaccination Coverage Adolescent Immunology medicine.disease_cause Rotavirus Infections 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine Humans 030212 general & internal medicine Child Pharmacology business.industry Immunization Programs Vaccination Infant Newborn Rotavirus Vaccines Infant Vaccine efficacy Rotavirus vaccine Hospitalization 030104 developmental biology Socioeconomic Factors Child Preschool Molecular Medicine sense organs medicine.symptom business Brazil |
| Zdroj: | Expert review of vaccines. 19(6) |
| ISSN: | 1744-8395 |
| Popis: | Monitoring the impact of vaccine programs is necessary to identify changes in vaccine efficacy. We report the impact of the 12-year rotavirus vaccine program on diarrhea mortality and hospitalizations and their correlation to socioeconomic indicators. this ecological study describes diarrhea hospitalizations and deaths from 2006 to 2018 in Brazil and correlates rotavirus vaccine coverage, hospitalizations and deaths to socioeconomic indicators and social vulnerability index (SVI) by state and region. Hospitalizations, deaths, and vaccine coverage trends were analyzed using Joinpoint regression models. Associations between hospitalizations, mortality and rotavirus vaccination coverage and socioeconomic and SVI indicators were established using Ordinary Least Square regressions. Rotavirus vaccine coverage remained stable between 2006 and 2018 (annual percentage changes (APC) [95%CI]: 4.4% [−0.3%, 9.2%]). Diarrhea hospitalization rates decreased 52.5% (−5.7% [−7.5%, −3.8%]), from 68.4 to 32.5 hospitalizations per 10,000 children |
| Databáze: | OpenAIRE |
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