Resuscitative efficacy of hemoglobin vesicles for severe postpartum hemorrhage in pregnant rabbits

Autor:	Morikazu Miyamoto, Manabu Kinoshita, Hiroki Ishibashi, Kohsuke Hagisawa, Tomoko Kure, Yukako Yuki, Hiromi Sakai, Masashi Takano, Katsuo Terui, Daizoh Saitoh
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Mean arterial pressure Resuscitation Science Drug development Hydroxyethyl starch Hemoglobin levels Article Hemoglobins Blood Substitutes Pregnancy medicine Animals Initial treatment Right uterine artery reproductive and urinary physiology Multidisciplinary business.industry Postpartum Hemorrhage Hemoglobin vesicles Experimental models of disease Disease Models Animal Red blood cell medicine.anatomical_structure Preclinical research Anesthesia Medicine Female Rabbits business medicine.drug
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports
ISSN:	2045-2322
Popis:	We aimed to investigate the resuscitative efficacy of hemoglobin vesicles (HbVs) as a red blood cell (RBC) substitute for the initial treatment of severe postpartum hemorrhage (PPH). Twenty-five pregnant rabbits underwent cesarean section; uncontrolled hemorrhage was induced by transecting the right uterine artery to establish a severe PPH model. During the first 30 min, all rabbits were administered 6% hydroxyethyl starch (HES) of an equivalent volume to the hemorrhage every 5 min. Thereafter, they received any of the following three isovolemic fluids for resuscitation every 5 min: RBCs with platelet-poor plasma (RBC/PPP) (n = 8), 6% HES (n = 7), or HbVs with 25% human serum albumin (n = 10). After surgical hemostasis at 60 min, survival was monitored until 12 h. No rabbits receiving only HES infusion survived beyond 6 h, whereas all rabbits receiving RBC/PPP transfusion survived. The rabbits receiving HbV infusion showed significantly higher mean arterial pressure and hemoglobin levels than the HES-receiving rabbits, and 8 of 10 rabbits survived for 6 h. The HbV group showed significantly higher survival than the HES group but worse survival than the RBC/PPP group. In conclusion, HbV infusion for severe PPH effectively prevents lethal hemorrhagic shock in a pregnant rabbit model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8daa0238a1db24b17cd0b45ba83239 https://doaj.org/article/a2bdc81d8b554053bc441c6ff5e5ea3b Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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