A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants
| Autor: | Jiří Friml, Yuree Lee, Markus Geisler, Jinsheng Zhu, Elke Barbez, Jürgen Kleine-Vehn, Chloé Béziat, Martin Kubeš, Petre I. Dobrev, Michel Ruiz Rosquete, Aleš Pěnčík, Bangjun Wang, Eva Zažímalová, Jakub Rolčík, Jan Petrášek |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
0106 biological sciences
Arabidopsis Intracellular Space Germination Saccharomyces cerevisiae Endoplasmic Reticulum Genes Plant 01 natural sciences 03 medical and health sciences Auxin Homeostasis heterocyclic compounds Promoter Regions Genetic 030304 developmental biology chemistry.chemical_classification 0303 health sciences Intracellular auxin transport Multidisciplinary biology Auxin homeostasis Indoleacetic Acids Arabidopsis Proteins Endoplasmic reticulum fungi food and beverages Compartmentalization (psychology) biology.organism_classification Plants Genetically Modified Cell biology chemistry Multigene Family Mutant Proteins Carrier Proteins Developmental biology Intracellular 010606 plant biology & botany |
| Zdroj: | Nature comm. |
| Popis: | The phytohormone auxin acts as a prominent signal, providing, by its local accumulation or depletion in selected cells, a spatial and temporal reference for changes in the developmental program. The distribution of auxin depends on both auxin metabolism (biosynthesis, conjugation and degradation) and cellular auxin transport. We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required for auxin-dependent regulation of plant growth by determining the cellular sensitivity to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signalling. PILS activity affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via intracellular accumulation and metabolism. Our findings reveal that the transport machinery to compartmentalize auxin within the cell is of an unexpected molecular complexity and demonstrate this compartmentalization to be functionally important for a number of developmental processes. |
| Databáze: | OpenAIRE |
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