Fibronectin-Grafted Titanium Dental Implants: An In Vivo Study
| Autor: | Che Tong Lin, Sheng Wei Feng, Yu Hwa Pan, Nai Chia Teng, Haw Ming Huang, Chia Hsun Chang, Kuo Ning Ho, Yu Chi Chang, Wei Jen Chang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
X-ray microtomography
Article Subject chemistry.chemical_element Dentistry lcsh:Medicine 02 engineering and technology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Dogs Coated Materials Biocompatible In vivo Bone-Implant Interface Surface roughness Medicine Animals Dental Implants Titanium General Immunology and Microbiology biology business.industry lcsh:R 030206 dentistry General Medicine X-Ray Microtomography 021001 nanoscience & nanotechnology Implant stability quotient Fibronectins Fibronectin Resonance frequency analysis chemistry biology.protein Implant 0210 nano-technology business Research Article |
| Zdroj: | BioMed Research International, Vol 2016 (2016) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Modification of the physiochemical properties of titanium surfaces using glow discharge plasma (GDP) and fibronectin coating has been shown to enhance the surface hydrophilicity, surface roughness, cell adhesion, migration, and proliferation. Thisin vivostudy aimed to evaluate the bone integration efficacy of a biologically modified implant surface. Two different surface-modified implants (Ar-GDP and GDP-fib) were placed in the mandibular premolar area of six beagle dogs for 2–8 weeks. Three techniques [histologic evaluation, resonance frequency analysis (RFA), and microcomputed tomography (micro-CT) evaluation] were used to detect the implant stability and bone-implant contact. The implant stability quotient values of GDP-fib implants were significantly greater than the Ar-GDP implants at 2 and 4 weeks (P<0.01). The bone volume/total volume ratio of GDP-fib implants was greater than the Ar-GDP implants in micro-CT evaluation. A high positive correlation was observed between RFA and micro-CT measurements. At 2 weeks, osteoblasts were seen to line the implant surface, and multinuclear osteoclasts could be seen on the surface of old parent bone. After 8 weeks, a majority of the space in the wound chamber appeared to be replaced by bone. Enhancement of the stability of biologically modified implants was proved by the results of RFA, micro-CT, and histological analysis. This enhanced stability may help fasten treatment and be clinically beneficial. |
| Databáze: | OpenAIRE |
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