Cloning and sequence analysis of the hemagglutinin gene of the virulent strain of rinderpest virus
| Autor: | Tracy Crisp, Marvin J. Grubman, Tilahun Yilma, David Hsu, Beverly Dale, Miles Yamanaka |
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| Rok vydání: | 1988 |
| Předmět: |
Base Sequence
biology Paramyxoviridae Sequence analysis Molecular Sequence Data Nucleic acid sequence Hemagglutinins Viral Hemagglutinin (influenza) Rinderpest virus biology.organism_classification Rinderpest Virology Molecular biology Virus Measles virus biology.protein Amino Acid Sequence Cloning Molecular |
| Zdroj: | Virology. 166:251-253 |
| ISSN: | 0042-6822 |
| Popis: | We have cloned the cDNA of the hemagglutinin (HA) gene of the virulent (Kabete O) strain of rinderpest virus and produced a comparative analysis of its sequence with that of the HA genes of rinderpest (lapinized strain) and measles viruses. The gene has an open reading frame of 1827 nucleotides, and the derived protein is 609 amino acids long with a calculated molecular weight of 68,006. The Kabete O HA polypeptide is identical in length to the HA of the lapinized strain of rinderpest virus and has a similar hydropathy profile. The nucleotide divergence between the lapinized and the Kabete O HA genes is 11.4% within the coding region, and 34.3% in the 3′ untranslated region. The two rinderpest HA polypeptides differ at 74 amino acid residues for a divergence of 12.2%. Three-way comparison of the two rinderpest HA molecules with the measles virus HA polypeptide indicates that 56.6% of the residues are conserved. |
| Databáze: | OpenAIRE |
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