Knockdown of CENPF Inhibits the Progression of Lung Adenocarcinoma Mediated by ERβ2/5 Pathway

Autor: Li Zhang, Weidong Hu, Lecai Xiong, Ming Xu, Zheng Tang, Xuefeng Zhou, Yanhong Wei, Zetian Yang, Hexiao Tang, Gaofeng Pan, Yi Cai, Michael Lanuti, Xiao Zhou, Minglin Zhu, Yuquan Bai, Jinping Zhao
Rok vydání: 2020
Předmět:
Popis: The signal transduction pathways of estrogen receptors (ER) mainly includes gene pathway and non-gene pathway. Studies have shown that the gene pathway of ER is related with the expression of nuclear proteins, and this is the key issue for our current research. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in adenocarcinoma of lung (LUAD), and the co-expression of CENPF and ERβ was found in the nucleus of LUAD cells. Meanwhile, CENPF and ERβ2/5 were related with T stage and poor prognosis (P
Databáze: OpenAIRE