Effect of chronic ANG I-converting enzyme inhibition on aging processes. I. Kidney structure and function
| Autor: | E. Ezan, Jacques Chevalier, Didier Heudes, A. Zimmerman, Odile Michel, B. Corman, E. Scalbert, Jean Bariety |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Aging medicine.medical_specialty Time Factors Physiology Renal glomerulus Renal function Angiotensin-Converting Enzyme Inhibitors Kidney Eating Reference Values Physiology (medical) Internal medicine Renin–angiotensin system Image Processing Computer-Assisted Perindopril medicine Animals Rats Wistar Chemistry Glomerular basement membrane Rats Microscopy Electron medicine.anatomical_structure Endocrinology Renal blood flow Renal physiology Glomerular Filtration Rate medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 266:R1038-R1051 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | The effect of angiotensin I-converting enzyme inhibition (ACEI) on the age-related changes in the kidney structure and function was investigated in rodents. Normotensive male Wistar (WAG)/Rij rats were treated with perindopril from the age of 6 mo to the day of killing at 12, 24, or 30 mo. Mean blood pressure, constant from 6 to 30 mo, was reduced by 19 mmHg in treated animals. With age, the major functional modifications were a decrease in glomerular filtration rate and in renal blood flow, a rise in intrarenal vascular resistance (IVR), a reduced tubular reabsorption of salts, and a progressive increase in proteinuria. ACEI significantly reduced IVR and proteinuria. From a structural point of view, the glomeruli showed 1) an increase in size, 2) a decrease in capillary surface, 3) a diffuse thickening of the glomerular basement membrane, 4) an expansion of the mesangial matrix, and 5) an accumulation of albumin droplets in podocytes inducing 6) a dispersed focal and segmental glomerulosclerosis which, at 30 mo, affected < 2% of glomeruli. Of these six age-related structural changes, ACEI delayed the appearance of the three latter changes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|