Presence of N-methyldopamine in parkinsonian and normal human brains
| Autor: | Toshimitsu Niwa, Kazuyoshi Watanabe, Naohito Takeda, Akira Tatematsu, Hideo Yoshizumi, Mitsuharu Kajita, Toshiharu Nagatsu |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Chromatography
Chemistry Parkinsonism Brain Parkinson Disease General Chemistry Isoquinolines Mass spectrometry medicine.disease Condensation reaction Gas Chromatography-Mass Spectrometry Methyldopamine Deoxyepinephrine Metabolic pathway Degenerative disease Salsoline Alkaloids Dopamine Tetrahydroisoquinolines medicine Humans Gas chromatography medicine.drug |
| Zdroj: | Journal of Chromatography B: Biomedical Sciences and Applications. 613:1-8 |
| ISSN: | 0378-4347 |
| DOI: | 10.1016/0378-4347(93)80190-f |
| Popis: | N-Methyldopamine (epinine) has been identified for the first time in parkinsonian and normal human brains by gas chromatography—mass spectrometry. N-Methylsalsolinol and N-methylnorsalsolinol, which are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces parkinsonism in humans, may be synthesized from N-methyldopamine by the Pictet—Spengler condensation reaction as an alternative metabolic pathway. |
| Databáze: | OpenAIRE |
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