Elastases from Human and Canine Granulocytes, II. Interaction with Protease Inhibitors of Animal, Plant, and Microbial Origin
| Autor: | Marianne Arnhold, Hans Fritz, Yehudith Birk, Inge Olsson, Kjell Ohlsson, Schiessler H |
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| Rok vydání: | 1977 |
| Předmět: |
Proteases
Protease Pancreatic Elastase medicine.medical_treatment Elastase Connective tissue Plants Biology Cathepsin G Biochemistry Streptomyces chemistry.chemical_compound Aprotinin Dogs medicine.anatomical_structure chemistry Leukocytes medicine Animals Humans Streptomyces griseoruber Trypsin Inhibitors Granulocytes |
| Zdroj: | Hoppe-Seyler´s Zeitschrift für physiologische Chemie. 358:53-58 |
| ISSN: | 0018-4888 |
| Popis: | Inhibitors of animal, plant, and microbial origin were tested against human and canine granulocytic elastases. The trypsin-chymotrypsin inhibitors from dog submandibular glands, from soybeans (Bowman-Birk) and from chickpeas show strong interaction with these proteases (Ki = 10(-8) - 10(-9)M). The trypsin-kallikrein inactivator of bovine organs (Trasylol) is not active against granulocytic elastases or against human granulocytic cathepsin G. Elastatinal, a specific inhibitor of elastases, isolated from actinomycetes (Streptomyces griseoruber), forms stable complexes with elastase from human (Ki = 6.2 X 10(-6)M) and canine granulocytes (Ki = 1.1 X 10(-6)M). A possible therapeutic application of these inhibitors for the inactivation of granulocytic proteases, which are able to degrade connective tissue in different pathological states, is discussed. |
| Databáze: | OpenAIRE |
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