[Corrigendum] FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment
| Autor: | Jin Liang, Xiao Chen, Minjie He, Hongxing Zhang, Chuanzheng Sun, Min Hong, Yuanyuan Xu, Weiqing Liu, Change Gao, Zhaoming Zhong |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research Epithelial-Mesenchymal Transition Cell Metastasis 03 medical and health sciences 0302 clinical medicine Cell Movement Cell Line Tumor Carcinoma medicine Tumor Microenvironment Humans Neoplasm Invasiveness Epithelial–mesenchymal transition Aged Neoplasm Staging Oncogene business.industry Cancer Cobalt General Medicine Cell cycle Middle Aged medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Prognosis Molecular medicine Cell Hypoxia Fibronectins Tongue Neoplasms medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Gene Knockdown Techniques Lymphatic Metastasis Cancer research Carcinoma Squamous Cell 030211 gastroenterology & hepatology Female business Corrigendum |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2020.7744 |
| Popis: | The primary reasons for the treatment failure of patients with oral tongue squamous cell carcinoma (OTSCC) are metastasis and tumor recurrence. Identifying the exact mechanisms underlying metastasis is a key point in improving patient prognosis. It has been reported that a hypoxic microenvironment plays an important role during the metastasis of malignancies. We found that the expression of fibronectin type III domain containing 3B (FNDC3B) is positively correlated with lymph node metastasis and advanced cTNM stage of OTSCC by IHC assay and correlation analysis. Furthermore, we found that knockdown of FNDC3B could suppress the migratory and invasive abilities of OTSCC cells. In addition, treating OTSCC cells with CoCl2 (a hypoxia mimetic agent) upregulated the mRNA and protein expression of FNDC3B via HIF-1α. Moreover, the resultant increase in FNDC3B expression significantly induced epithelial-mesenchymal transition (EMT) in OTSCC cells. The present study elucidated the important role played by FNDC3B in OTSCC metastasis and indicates FNDC3B as a potential target for the treatment of OTSCC metastasis. However, many questions remain to be explored. |
| Databáze: | OpenAIRE |
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