The effect of arabinoxylooligosaccharides on upper gastroduodenal motility and hunger ratings in humans
| Autor: | Kristin Verbeke, Eveline Deloose, Emidio Scarpellini, Willem F. Broekaert, Rita Vos, IE Francois, Jan A. Delcour, Jan Tack |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male FOOD-INTAKE Physiology Hunger Oligosaccharides Gastroenterology APPETITE Medicine Single-Blind Method media_common Morning Gastrointestinal tract Meal Myoelectric Complex Migrating Cross-Over Studies digestive oral and skin physiology GUT MICROBIOTA high-resolution manometry CHAIN FATTY-ACIDS OBESITY Female HEALTH Life Sciences & Biomedicine Adult medicine.medical_specialty Duodenum Manometry media_common.quotation_subject Clinical Neurology FIBER METABOLISM Placebo hunger Excretion 03 medical and health sciences GASTROINTESTINAL MOTILITY AXOS Internal medicine ARABINOXYLAN-OLIGOSACCHARIDES Gastroduodenal motility Humans Gastrointestinal Transit Migrating motor complex 030109 nutrition & dietetics Science & Technology Gastroenterology & Hepatology Endocrine and Autonomic Systems business.industry Neurosciences Appetite Prebiotics Neurosciences & Neurology business Gastrointestinal Motility |
| Popis: | BACKGROUND AND AIMS: Prebiotics such as Arabinoxylooligosaccharides (AXOS) are non-digestible, fermentable food ingredients stimulating growth/activity of colonic bacteria with enhanced carbohydrates fermentation (CF) in humans. The migrating motor complex (MMC) of the gastrointestinal tract has been recently identified as an important hunger signal, but no data are available yet on the role of acute CF on MMC activity and related hunger ratings. Thus, we aimed to study the effect of acute AXOS CF on MMC and hunger in humans. METHODS: A total of 13 healthy volunteers were randomized in a single-blind crossover placebo-controlled study where 9.4 g of AXOS or 10 g of maltodextrin and 1 g of unlabelled lactose ureide (LU) were given 12 hours prior to the study and, in the next morning, together with a pancake containing 500 mg of 13 C-LU. In 10 hours after the meal, 13 CO2 and hydrogen excretion were determined every 15 minutes while hunger/appetite ratings every 2 minutes through a VAS questionnaire. Five hours after the meal, antroduodenal motility was measured using HRM. KEY RESULTS: AXOS significantly increased CF (158 ± 81 vs 840 ± 464 H2 ppm*minute, placebo vs AXOS, P |
| Databáze: | OpenAIRE |
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