Evaluation of antibiotic efficacy using electron microscopy: morphological effects of guanylureido cephalosporin, chlorobenzoylureido cephalosporin, BL-P1654, and carbenicillin on Pseudomonas aeruginosa
| Autor: | L. F. Ellis, L. K. Simmons, David A. Preston, D. K. Herron, R. A. Schlegel |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Cell division
medicine.drug_class Antibiotics Cephalosporin Penicillanic Acid Microbial Sensitivity Tests Penicillins Biology medicine.disease_cause Guanidines Microbiology Minimum inhibitory concentration Mice Leucine Physiological Effects and Microbial Susceptibility medicine Animals Pharmacology (medical) Pseudomonas Infections Incubation Pharmacology Pseudomonas aeruginosa Spheroplast Carbenicillin Cephalosporins Chlorobenzoates Infectious Diseases Microscopy Electron Scanning medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 9(2) |
| ISSN: | 0066-4804 |
| Popis: | The response of Pseudomonas aeruginosa to carbenicillin, BL-P1654, and two cephalosporins (112384 and 112883) was evaluated by minimal inhibitory concentration determinations, [ 14 C]leucine uptake studies, morphological studies of colonial growth, and mouse intraperitoneal inoculations. Spheroplast formation and bacterial lysis were not the early response; instead, cell division was inhibited and long filaments were formed. Spheroplast formation and bacterial lysis were not observed in the first 7 h of incubation in minimal inhibitory concentrations of antibiotic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|