Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil.Naudin (Malvaceae) in rodents
| Autor: | Mariana Helena Chaves, Francisco Artur Forte Oliveira, Kayo Alves Figueiredo, Francilene V. Silva, Fernanda R.C. Almeida, Danielly Albuquerque da Costa, Maurício P.M. Amaral, Irisdalva S. Oliveira, Francisco B. Melo Júnior, Rita de Cássia Meneses Oliveira |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.drug_class Anti-Inflammatory Agents Medicine (miscellaneous) Glutamic Acid Pain Sterculia Pharmacology Carrageenan Anti-inflammatory chemistry.chemical_compound Acetic acid Mice Edema Formaldehyde medicine Animals Rats Wistar Acetic Acid Inflammation Analgesics Nutrition and Dietetics biology Plant Stems Naloxone Plant Extracts Dextrans biology.organism_classification Dextran Nociception chemistry Biochemistry Capsaicin Plant Bark medicine.symptom Histamine Phytotherapy |
| Zdroj: | Journal of medicinal food. 17(6) |
| ISSN: | 1557-7600 |
| Popis: | The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil.Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50 mg/kg) promoted a marked inhibition on the hind paw edema induced by carrageenan or dextran (30% and 73%, respectively). Besides, Ss-EtOH (25 mg/kg) exhibited a slight activity (30%) on the hind paw edema induced by histamin. The Ss-EtOH (12.5 and 25 mg/kg) showed the antinociceptive activity on chemical stimuli induced by acetic acid (65.59% and 38.37%, respectively), formalin, in the initial (35.08% and 31.5%, respectively) and late phases (44.09% and 83.57%, respectively), capsaicin (43.77% and 51.31%, respectively), or glutamate (36.6% and 52.12%, respectively). Regarding the possible mechanism involved in the antinociceptive effect, Ss-EtOH (12.5 mg/kg) showed a decrease in the antinociceptive effect (65.8%) in the acetic acid model after pretreatment with naloxone. Thus, opioid mechanisms might be underlying this response. |
| Databáze: | OpenAIRE |
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