Analysis of peripheral blood lymphocyte phenotype and function during dexamethazone treatment of progressive multiple sclerosis
| Autor: | Clara Milanese, M. Sandberg-Wollheim, R. Parma, Angelo Nespolo, Bo Baldetorp, Andrea Salmaggi |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Male medicine.medical_specialty Multiple Sclerosis Lymphocytosis CD3 Complex Lymphocyte CD4-CD8 Ratio Receptors Antigen T-Cell Lymphocyte Activation Peripheral blood mononuclear cell Dexamethasone Immunophenotyping Leukocyte Count Internal medicine medicine Humans Neurologic Examination business.industry Pokeweed mitogen Multiple sclerosis Granulocytosis General Medicine HLA-DR Antigens Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Neurology Peripheral blood lymphocyte Immunology Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Acta neurologica Scandinavica. 84(2) |
| ISSN: | 0001-6314 |
| Popis: | Five patients with chronic progressive multiple sclerosis (MS) and three control patients with lumbar disc herniation were treated with dexamethazone during 14 days. The effect on peripheral blood T-cell subsets and on the proliferative response of peripheral blood mononuclear cells (PBMC) to pokeweed mitogen (PWM) and anti-mu antibody was analyzed. Before treatment, the proportion of CD3+ and CD4+ PBMC was similar in MS and control patients, but the proportion of CD8+ and DR+ PBMC was lower and the PBMC were less responsive to anti-mu stimulation in MS patients compared to controls. Steroid treatment induced reversible granulocytosis and lymphocytosis. CD3+ and CD4+ cells increased and DR+ cells decreased in MS patients but not in controls. Proliferation of anti-mu stimulated PBMC increased in MS-patients during the two weeks of treatment, but decreased in controls. The enhancement in the MS patients of pre-existing immune abnormalities suggests that a cautious attitude is warranted in the use of steroid treatment in chronic progressive MS. |
| Databáze: | OpenAIRE |
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