Integrated expression analysis revealed RUNX2 upregulation in lung squamous cell carcinoma tissues

Autor:	Shang-Wei Chen, Gang Chen, Chang-Bo Li, Jie Yang, Jian-Hua Song, Zhong-Qing Tang, Lin-Jie Yang, Hui-Ping Lu, Da-Ping Yang, Jun-Xian Mo, Li Gao, Jin-Liang Kong, Hua-Fu Zhou
Rok vydání:	2020
Předmět:	Lung Neoplasms Protein digestion 0206 medical engineering Core Binding Factor Alpha 1 Subunit 02 engineering and technology Biology 03 medical and health sciences Downregulation and upregulation stomatognathic system Genetics medicine Humans Molecular Biology 030304 developmental biology Oligonucleotide Array Sequence Analysis 0303 health sciences Microarray analysis techniques Cancer Cell Biology medicine.disease 020601 biomedical engineering Hedgehog signaling pathway RUNX2 Gene Expression Regulation Neoplastic Modeling and Simulation Cancer research Carcinoma Squamous Cell Immunohistochemistry DNA microarray Biotechnology Research Article
Zdroj:	IET Syst Biol
ISSN:	1751-8857
Popis:	This study aimed to investigate the clinicopathological significance and prospective molecular mechanism of RUNX family transcription factor 2 (RUNX2) in lung squamous cell carcinoma (LUSC). The authors used immunohistochemistry (IHC), RNA‐seq, and microarray data from multi‐platforms to conduct a comprehensive analysis of the clinicopathological significance and molecular mechanism of RUNX2 in the occurrence and development of LUSC. RUNX2 expression was significantly higher in 16 LUSC tissues than in paired non‐cancerous tissues detected by IHC (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac86067f67e5a8b2491da749780d8f18 https://pubmed.ncbi.nlm.nih.gov/33095746 Zobrazit plný text záznamu Plný text