The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis
| Autor: | Lisa Zarantonello, Carmina Montoliu, Maria J. Barcenas Jimenez, Matteo Turco, Paolo Angeli, Paula Izquierdo‐Altarejos, Chiara Formentin, Anna Vuerich, Sara Montagnese, Piero Amodio, Vicente Felipo |
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| Rok vydání: | 2018 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Psychometrics Neuropsychological Tests 03 medical and health sciences learning ability 0302 clinical medicine Model for End-Stage Liver Disease Cognition Internal medicine Reaction Time Medicine Humans Learning In patient Hepatic encephalopathy Aged Hepatology Choice reaction time medicine.diagnostic_test business.industry cirrhosis Neuropsychological test Middle Aged medicine.disease hepatic encephalopathy neuropsychological test 030220 oncology & carcinogenesis Hepatic Encephalopathy 030211 gastroenterology & hepatology Female business human activities |
| Zdroj: | Liver international : official journal of the International Association for the Study of the Liver. 39(5) |
| ISSN: | 1478-3231 |
| Popis: | BACKGROUND & AIMS Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests. METHODS Two hundred and fourteen patients with cirrhosis were enrolled. On the day of study, 41% were classed as unimpaired, 38% as having minimal HE and 21% as having mild OHE; 58% had a history of OHE. Performance was compared between two versions of the trail-making test A (TMT-A), and between the first/second half of a simple/choice reaction time (sRT and cRT), and a working memory test (ScanRT). RESULTS Both patients with and without OHE history improved in TMT-A, sRT and ScanRT. Only patients with no OHE history improved in cRT. All patients, regardless of their HE status on the day of study, improved in TMT-A and sRT. Only patients with mild OHE on the day of study improved in cRT. Only unimpaired patients improved in ScanRT. When OHE history and HE status on the day of study were tested together, only HE status had an effect. The same held true when age, the Model for End Stage Liver Disease (MELD) and educational attainment were adjusted for. CONCLUSIONS HE status on the day of study and the type of neuropsychological test had an effect on learning ability in a well-characterized group of patients with cirrhosis. |
| Databáze: | OpenAIRE |
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