Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study

Autor: Tuncay Altug, Necdet Sut, D. Azria, A. Ober, A. Altinok, Nuran Bese, Sukru Yildirim, E. M. Ozsahin
Přispěvatelé: Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Rok vydání: 2016
Předmět:
0301 basic medicine
MESH: Radiotherapy
Pulmonary Fibrosis
Group A
Group B
0302 clinical medicine
Fibrosis
Medicine
MESH: Animals
MESH: Aromatase Inhibitors
Aromatase
biology
Aromatase Inhibitors
Letrozole
General Medicine
MESH: Antineoplastic Agents
Hormonal
Radioprotective Effect
MESH: Nitriles
3. Good health
Radiation Injuries
Experimental
medicine.anatomical_structure
MESH: Chemotherapy
Adjuvant
Chemotherapy
Adjuvant
MESH: Letrozole
030220 oncology & carcinogenesis
Female
medicine.drug
medicine.medical_specialty
MESH: Anastrozole
MESH: Rats
Antineoplastic Agents
Hormonal
Urology
Radiation Therapy
[SDV.CAN]Life Sciences [q-bio]/Cancer
Anastrozole
03 medical and health sciences
Statistical significance
Internal medicine
Breast Cancer
Nitriles
Animals
Rats
Wistar
Lung
MESH: Pulmonary Fibrosis
Radiotherapy
business.industry
MESH: Rats
Wistar
Triazoles
medicine.disease
Rats
Androstadienes
Tamoxifen
030104 developmental biology
Endocrinology
MESH: Triazoles
MESH: Androstadienes
MESH: Radiation Injuries
Experimental
biology.protein
MESH: Tamoxifen
Surgery
business
MESH: Female
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Breast
Breast, Elsevier, 2016, 28, pp.174-177. ⟨10.1016/j.breast.2016.04.003⟩
ISSN: 1532-3080
0960-9776
Popis: IEEE Conference on Standards for Communications and Networking, CSCN 2015 -- 28 October 2015 through 30 October 2015 -- 119154 Purpose: In experimental and clinical trials, tamoxifen (TAM) has been shown to increase radiation-induced lung fibrosis (RILF). Furthermore, aromatase inhibitors (AI) have been shown to be superior to TAM in the adjuvant setting and preclinical data suggest that letrozole (LET) sensitizes breast cancer cells to ionizing radiation in other studies. In this experimental study, we evaluated whether AI have any impact on the development of RILF in rats. Materials and methods: 60 female wistar- albino rats were divided into 6 groups: Control (group A), RT alone (group B), RT + TAM (group C), RT + anastrozole (ANA group D), RT + LET (group E), and RT + exemestane (EXE, group F). RT consisted of 30 Gy in 10 fractions to both lungs with an anterior field at 2 cm depth. Equivalent doses for 60 kg adult dose per day of TAM, ANA, LET, and EXE were calculated according to the mean weight of rats and orally administrated with a feeding tube. Percentage of lung with fibrosis was quantified with image analysis of histological sections of the lung. The mean score values were calculated for each group. the significance of the differences among groups were calculated using one way ANOVA test and Tukey HSD post-hoc test. Results: Mean values of fibrosis were 1.7, 5.9, 6.7, 2.5, 2 and 2.2 for groups A, B, C, D, E, and F, respectively (p = 0.000). TAM increased RT-induced lung fibrosis but without statistical significance. Groups treated with RT + AI showed significantly less lung fibrosis than groups treated with RT alone or RT + TAM (p = 0.000). RT + AI groups showed nearly similar RT-induced lung fibrosis than control group. Conclusions: In this study, we found that AI decreased RT-induced lung fibrosis to the control group level suggesting protective effect.
Databáze: OpenAIRE
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