Screening for celiac disease, by endomysial antibodies, in patients with unexplained articular manifestations
| Autor: | Rafiaa Nouira, F. Bahri, Ibtissem Ghedira, Elyes Bouajina, Amani Mankaï, Wahiba Sakly, Chedia Kechrid, Mariam Ghozzi |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Tunisia Anemia Immunology Arthritis Gastroenterology Serology Diagnosis Differential Young Adult Sex Factors Rheumatology GTP-Binding Proteins Predictive Value of Tests Risk Factors Internal medicine medicine Humans Immunology and Allergy Protein Glutamine gamma Glutamyltransferase 2 Serologic Tests Aged Autoantibodies Retrospective Studies Aged 80 and over Transglutaminases business.industry Middle Aged medicine.disease Arthralgia Immunoglobulin A Surgery Osteopenia Celiac Disease Predictive value of tests Female Differential diagnosis business Biomarkers |
| Zdroj: | Rheumatology International. 34:637-642 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-013-2906-x |
| Popis: | Celiac disease (CD) is an autoimmune systemic disease characterized by not only gastrointestinal but also extraintestinal manifestations. The aim of our study was to do a serological screening for CD, by IgA endomysial antibodies (EmA), in patients with unexplained articular manifestations. Two hundred and eleven patients suffering from arthritis or arthralgia without evident cause were studied. EmA were determined by indirect immunofluorescence on human umbilical cord. Two thousand and five hundred blood donors served as control group. Out of 211 patients, 5 had EmA (2.37 %). The frequency of EmA in our patients was significantly higher than in the control group (2.37 vs. 0.28 %, p < 0.01). All patients with positive EmA were female. EmA were significantly more frequent in female patients than in female healthy subjects (3 vs. 0.4 %, p < 0.01). Medical records revealed: diarrhea (one patient), short size (one patient), anemia (three patients), weight loss (two patients) spontaneous abortion (three patients), secondary amenorrhea (one patient), early menopause (one patient) and early baby death (one patient). Biochemical analysis showed decreased level of calcium (one patient), vitamin D (one patient) and cholesterol (one patient). Unexplained liver cytolysis was observed in two patients. Radiological examination showed demineralization of two hands in one patient. Bone osteodensitometry done in one patient out of five revealed lumbar osteopenia. The articular manifestations of the five patients did not respond to corticosteroid treatment. CD must be considered among the differential diagnosis in a patient with arthritis or arthralgia. |
| Databáze: | OpenAIRE |
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