FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats
| Autor: | Nilla Orthen-Gambill, Melinda Salomon |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty media_common.quotation_subject Period (gene) Central nervous system Hypothalamus Experimental and Cognitive Psychology Histidine Decarboxylase Body weight Behavioral Neuroscience chemistry.chemical_compound Eating Feeding behavior Internal medicine medicine Animals media_common Chemistry Body Weight Appetite Rats Inbred Strains Metabolism Methylhistidines Rats Endocrinology medicine.anatomical_structure Histamine |
| Zdroj: | Physiologybehavior. 51(4) |
| ISSN: | 0031-9384 |
| Popis: | The present study tested the long-term effects of the histamine (H) synthesis inhibitor alpha-fluoromethylhistidine (FMH) on feeding and body weight in rats. FMH (administered via 2-week osmotic minipumps) increased feeding significantly throughout the test period. Body weights were also significantly increased toward the end of the test period. Hypothalamic H assays, performed at the end of the study, confirmed that FMH-treated rats had significantly lower H levels than controls. In general, the results suggest that H activity and feeding are inversely related. |
| Databáze: | OpenAIRE |
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