5-Caffeoylquinic Acid Ameliorates Cognitive Decline and Reduces Aβ Deposition by Modulating Aβ Clearance Pathways in APP/PS2 Transgenic Mice
| Autor: | Koichi Misawa, Ishida Keiko, Tomoya Hirata, Nishimura Hitomi, Masaki Yamamoto, Noriyasu Ota |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Male chlorogenic acid Quinic Acid lcsh:TX341-641 Mice Transgenic Pharmacology Coffee Article amyloid-β clearance 03 medical and health sciences 0302 clinical medicine Cognition Downregulation and upregulation Alzheimer Disease mental disorders Animals Cognitive Dysfunction aquaporin 4 Cognitive decline coffee polyphenol Receptor low-density lipoprotein receptor related protein 1 cognitive function LDL-Receptor Related Proteins Nutrition and Dietetics Amyloid beta-Peptides Chemistry 5-caffeoylquinic acid Brain Polyphenols Caffeoylquinic acid Disease Models Animal 030104 developmental biology Aquaporin 4 APP/PS2 mice Female Efflux lcsh:Nutrition. Foods and food supply Alzheimer’s disease 030217 neurology & neurosurgery Food Science Lipoprotein Phytotherapy |
| Zdroj: | Nutrients Nutrients, Vol 12, Iss 2, p 494 (2020) Volume 12 Issue 2 |
| ISSN: | 2072-6643 |
| Popis: | The accumulation of amyloid &beta (A&beta ) in the brain is a major pathological feature of Alzheimer&rsquo s disease (AD). In our previous study, we demonstrated that coffee polyphenols (CPP) prevent cognitive dysfunction and A&beta deposition in the brain of an APP/PS2 transgenic mouse AD model. The underlying mechanisms, however, remain to be elucidated. Here, we investigated the effects of the chronic administration of 5-caffeoylquinic acid (5-CQA), the most abundant component of CPP, on cognitive dysfunction in APP/PS2 mice to identify the role of CPP in A&beta elimination. Relative to the untreated controls, the mice fed a 5-CQA-supplemented diet showed significant improvements in their cognitive function assessed by Y-maze and novel object recognition tests. Histochemical analysis revealed that 5-CQA substantially reduced A&beta plaque formation and neuronal loss in the hippocampi. Moreover, 5-CQA upregulated the gene encoding low-density lipoprotein receptor-related protein 1, an A&beta efflux receptor, and normalized the perivascular localization of aquaporin 4, which facilitates A&beta clearance along the paravascular pathway. These results suggest that 5-CQA reduces A&beta deposition in the brain by modulating the A&beta clearance pathways and ameliorating cognitive decline and neuronal loss in APP/PS2 mice. Thus, 5-CQA may be effective in preventing cognitive dysfunction in AD. |
| Databáze: | OpenAIRE |
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