Applications of the amino-Cope rearrangement: synthesis of tetrahydropyran, delta-lactone and piperidine targets
| Autor: | Mark R. J. Elsegood, Pritom Shah, Vickie McKee, Catarina Horro Pita, Munira Essat, Steven M. Allin, Robert D. Baird, David M. Andrews, Mark Edgar, Ian Aspinall |
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| Rok vydání: | 2005 |
| Předmět: |
Molecular Structure
Stereochemistry Organic Chemistry Molecular Conformation Stereoisomerism Tetrahydropyran Crystallography X-Ray Biochemistry Combinatorial chemistry chemistry.chemical_compound Lactones chemistry Piperidines Cyclization Piperidine Physical and Theoretical Chemistry δ lactone Cope rearrangement Pyrans |
| Zdroj: | Organicbiomolecular chemistry. 3(5) |
| ISSN: | 1477-0520 |
| Popis: | We report a novel approach to some chiral tetrahydropyran and delta-lactone targets that utilizes the asymmetric amino-Cope rearrangement as a key synthetic step. Products of amino-Cope rearrangement chemistry have also been applied to access piperidine targets, further demonstrating the potential of the methodology. |
| Databáze: | OpenAIRE |
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