Hyponatremia as a prognostic and predictive factor in metastatic renal cell carcinoma
| Autor: | Niels Marcussen, Hanne Krogh Jensen, A. N. Jeppesen, Frede Donskov, H. von der Maase |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male renal cell carcinoma Cancer Research Pathology medicine.medical_specialty Adolescent urologic and male genital diseases Gastroenterology Cohort Studies Young Adult Renal cell carcinoma Internal medicine Carcinoma Humans Medicine predictive Molecular Diagnostics neoplasms Carcinoma Renal Cell Survival rate Aged Retrospective Studies business.industry Sodium Retrospective cohort study Middle Aged Prognosis medicine.disease mortality female genital diseases and pregnancy complications Carcinoma Papillary Kidney Neoplasms metastatic Survival Rate Oncology Cohort Female business Hyponatremia Kidney cancer Follow-Up Studies Cohort study |
| Zdroj: | Jeppesen, A N, Jensen, H K, Donskov, F, Marcussen, N & von der Maase, H 2010, ' Hyponatremia as a prognostic and predictive factor in metastatic renal cell carcinoma ', British Journal of Cancer, vol. 102, no. 5, pp. 867-72 . https://doi.org/10.1038/sj.bjc.6605563 British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Low serum sodium has recently been associated with poor survival in localised renal cell carcinoma (RCC). We now show the prognostic effect of serum sodium in patients with metastatic RCC (mRCC). Methods: Cohort A comprised 120 consecutive patients with mRCC receiving subcutaneous, low-dose interleukin-2 and interferon-α. Hyponatremia was assessed in univariate and multivariate analyses. An independent cohort of another 120 patients with mRCC was used for validation (cohort B). Results: In cohort A, estimated 5-year survival was 15% and median survival was 15.1 months. Serum sodium ranged between 126 and 144 mM. Twenty-four patients (20%) had serum sodium levels below normal range (1.5 upper normal level (P=0.002), and number of metastatic sites (+3) (P=0.003). In cohort B, serum sodium ranged between 128 and 146 mM. Seventeen patients (14%) had sodium levels below normal range. In multivariate analysis, serum sodium was validated as an independent prognostic factor (P=0.001). A significant association between lack of response and hyponatremia was observed in both cohorts (P=0.003 and P=0.02, respectively). Conclusion: Low serum sodium is a new, validated, independent prognostic, and predictive factor in patients with mRCC. |
| Databáze: | OpenAIRE |
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