The clinical significance of standardized uptake value in breast cancer measured using 18F-fluorodeoxyglucose positron emission tomography/computed tomography
| Autor: | Jong Min Baek, Young-Hwa Kim, Gi-Young Sung, Jina Lee, Dosang Lee, Jong-Man Won |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Breast Neoplasms Standardized uptake value Computed tomography Multimodal Imaging Fluorodeoxyglucose positron emission tomography Breast cancer Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Clinical significance skin and connective tissue diseases Aged Aged 80 and over medicine.diagnostic_test business.industry Biological Transport General Medicine Middle Aged Prognosis medicine.disease carbohydrates (lipids) Biological significance Positron-Emission Tomography Female Radiology Tomography X-Ray Computed Nuclear medicine business |
| Zdroj: | Nuclear Medicine Communications. 36:790-794 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0000000000000330 |
| Popis: | The objective of this study was to investigate the clinical and biological significance of F-fluorodeoxyglucose (F-FDG) uptake levels in breast cancer patients.F-FDG PET/computed tomography was performed in 206 women with breast cancer, and the standardized uptake value (SUV) in breast cancer was analyzed to test associations with prognostic parameters.PET/computed tomography sensitivity for primary tumor detection was 90.4% (206/228) and sensitivity and specificity for metastatic axillary lymph node were 72.6% (45/62) and 84.7% (122/144), respectively. A high SUV was significantly associated with large tumor size (2 cm, P0.001), positive axillary lymph node metastasis (P0.001), distant metastasis (P=0.016), higher tumor node metastasis stage (P0.001), higher histologic grade (P0.001), higher nuclear grade (P0.001), estrogen receptor negativity (P0.001), progesterone receptor negativity (P0.001), triple negativity (P=0.006), B-cell lymphoma/leukemia-2 negativity (P=0.031), cytokeratin 5/6 positivity (P=0.001), epidermal growth factor receptor positivity (P=0.005), and Ki67 positivity (P=0.003). Multivariate analysis showed that tumor size (2 cm, P=0.001), positive axillary lymph node metastasis (P=0.028), and estrogen receptor negativity (P0.001) were significantly associated with the SUV.High levels of F-FDG uptake in primary breast cancer were correlated with poor prognostic factors and aggressive biologic markers such as triple negativity, markers of basal-type cancer, and Ki67. The SUV might be predictive of biologic markers and assist therapeutic decision making. |
| Databáze: | OpenAIRE |
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