Dilemmas in Human and Rat Pregnancy: Proposed Mechanisms Relating to Arterial Vasodilation
| Autor: | R. W. Schrier, M. Ohara |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Vasopressin Vascular smooth muscle Endocrinology Diabetes and Metabolism Blood volume Vasodilation Nitric Oxide Oxytocin Renin-Angiotensin System Cellular and Molecular Neuroscience Endocrinology Polyuria Pregnancy Internal medicine Renin–angiotensin system medicine Animals Humans Endocrine and Autonomic Systems Reabsorption business.industry Arteries medicine.disease Rats Arginine Vasopressin Pregnancy Complications Female medicine.symptom business Diabetes Insipidus |
| Zdroj: | Journal of Neuroendocrinology. 22:400-406 |
| ISSN: | 1365-2826 0953-8194 |
| DOI: | 10.1111/j.1365-2826.2010.01948.x |
| Popis: | There are several mysteries about the normal physiology of pregnancy (1). Renal sodium and water reabsorption occurs despite an increase in total blood volume. Moreover, the renin-angiotensin-aldosterone system (RAAS) is also stimulated in normal pregnancy, even though an increase in total blood volume normally suppresses the RAAS and increases sodium excretion in the nonpregnant state. Water retention also occurs and leads to hypoosmolality in normal pregnancy, even though total blood volume is expanded. On rare occasions, an extreme polyuria occurs in pregnancy that is unresponsive to arginine vasopressin (AVP). The receptors whereby AVP and oxytocin stimulate the principal cell of the collecting duct, vascular smooth muscle, glomerular mesangial and endometrial cells are in need of clarification. The present study proposes potential mechanisms relating to systemic arterial vasodilation to explain some of the apparent dilemmas of pregnancy. |
| Databáze: | OpenAIRE |
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