Early age noise exposure increases loudness perception - A novel animal model of hyperacusis
| Autor: | Binbin Xiong, Richard Salvi, Ana'am Alkharabsheh, Fen Xiong, Senthilvelan Manohar, Guang-Di Chen, Wei Sun |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Loudness Perception Time Factors Hearing loss Audiology Loudness Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Noise exposure Animal model Hearing Risk Factors otorhinolaryngologic diseases medicine Evoked Potentials Auditory Brain Stem Reaction Time Animals Significant risk 030223 otorhinolaryngology Behavior Animal Hyperacusis Age Factors Sensory Systems Noise Disease Models Animal Acoustic Stimulation Hearing Loss Noise-Induced Conditioning Operant medicine.symptom Psychology psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Hearing research. 347 |
| ISSN: | 1878-5891 |
| Popis: | The neural mechanisms that give rise to hyperacusis, a reduction in loudness tolerance, are largely unknown. Some reports suggest that hyperacusis is linked to childhood hearing loss. However, the evidence for this is largely circumstantial. In order to rigorously test this hypothesis, we studied loudness changes in rats caused by intense noise exposure (12 kHz narrow band noise, 115 dB SPL, 4 h) at postnatal 16 days. Rats without noise exposure were used as controls. The exposed noise group (n = 7) showed a mean 40-50 dB hearing loss compared to the control group (n = 8) at high frequencies (>= 8 kHz) and less hearing loss at lower frequencies. Loudness was evaluated using sound reaction time and loudness response functions in an operant conditioning-based behavioral task using narrow-band noise (40-110 dB SPL, centered at 2, 4 and 12 kHz). Interestingly, the sound reaction time of the noise group was significantly shorter than the control group at supra-threshold levels. The average reaction time was less than 100 ms in the noise group at 100 dB SPL, which was three times shorter than the control group. Our results indicate that early noise-induced hearing loss leads to a significant increase of loudness, a behavior indicative of hyperacusis. Our results are consistent with clinical reports suggesting that hearing loss at an early age is a significant risk factor for hyperacusis. |
| Databáze: | OpenAIRE |
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