Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden

Autor: Zarife Nigâr Ozdemir-Kumral, Eminenur Sen, Hasan Basri Yapici, Nurullah Atakul, Omer Faruk Domruk, Yusra Aldag, Leyla Semiha Sen, Fatma Kanpalta Mustafaoğlu, Meral Yuksel, Dilek Akakin, Can Erzik, Goncagul Haklar, Neşe imeryuz
Přispěvatelé: ÖZDEMİR KUMRAL Z. N. , Sen E., Yapici H. B. , Atakul N., Domruk O. F. , Aldag Y., Sen L. S. , Mustafaoglu F. K. , YÜKSEL M., AKAKIN D., et al.
Rok vydání: 2022
Předmět:
Male
Blood Glucose
STRESS
MPO
Pharmaceutical Science
Pharmacy
Sağlık Bilimleri
Rats
Sprague-Dawley
TESTOSTERONE
FARMAKOLOJİ VE ECZACILIK
Insulin
Pharmacology (medical)
PEPTIDE
General Pharmacology
Toxicology and Pharmaceutics
glucose
PHARMACOLOGY & PHARMACY
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
DAMAGE
PHARMACOLOGY & TOXICOLOGY
SITES
Temel Bilimler
Basic Pharmaceutics Sciences
Life Sciences
Genel Farmakoloji
Toksikoloji ve Eczacılık
Farmakoloji (tıbbi)
İlaç Rehberleri
Farmakoloji ve Toksikoloji
SECRETION
Natural Sciences
NESFATIN-1
EXPRESSION
Farmakoloji
Life Sciences (LIFE)
free radicals
Streptozocin
Diabetes Mellitus
Experimental
gastric emptying
Drug Guides
Yaşam Bilimleri
Health Sciences
Animals
Farmakoloji
Toksikoloji ve Eczacılık (çeşitli)
MODULATION
Eczacılık
Pharmacology
Pharmacology and Therapeutics
Rats
Oxidative Stress
Temel Eczacılık Bilimleri
Yaşam Bilimleri (LIFE)
inflammation
ORAL GLUCOSE-TOLERANCE
Zdroj: Journal of Pharmacy and Pharmacology. 74:1651-1659
ISSN: 2042-7158
0022-3573
Popis: Phoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol/kg, or 45 nmol/kg) daily for 3 days 1 week after STZ injection. Fasting blood glucose (FBG) and gastric emptying rate (GER) were measured. Tissue and blood samples were collected. PNX treatments prevented pancreatic damage and β cell loss. Increased luminol and lucigenin levels in the pancreas, ileum and liver tissues of STZ groups were alleviated by PNX treatment in pancreatic and ileal tissues. PNX0.45 decreased FBG without any change in insulin blood level and pancreatic mRNA. GER increased in all diabetic rats while PNX0.45 delayed GER only in the C group. PNX diminishes pancreatic damage and lowers FBG by reducing oxidative load.
Databáze: OpenAIRE
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