A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics
| Autor: | Natalia Blanca-Lopez, Jean-Louis Guéant, M.J. Torres, Antonino Romano, Inmaculada Doña, Gabriela Canto, Thomas Josse, D. Tramoy, Rosa-Maria Guéant-Rodriguez, Jose A. Cornejo-Garcia, Abderrahim Oussalah, Francesco Gaeta, M. Blanca |
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| Přispěvatelé: | Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Biomedical Research Institute of Málaga (IBIMA), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Complesso Integrato Columbus, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Hypersensitivity Immediate Male Allergy Galectin 3 Galectins [SDV]Life Sciences [q-bio] Drug allergy beta-Lactams Immunoglobulin E Polymorphism Single Nucleotide Drug Hypersensitivity Atopy 03 medical and health sciences 0302 clinical medicine Genetics medicine Humans Gene Pharmacology biology Settore MED/09 - MEDICINA INTERNA Case-control study Blood Proteins Exons Odds ratio Middle Aged medicine.disease Anti-Bacterial Agents Protein Structure Tertiary 3. Good health Italy 030228 respiratory system Spain Galectin-3 Case-Control Studies Immunology biology.protein Molecular Medicine Female 030215 immunology |
| Zdroj: | Pharmacogenomics Journal Pharmacogenomics Journal, Nature Publishing Group, 2016, 16 (1), pp.79-82. ⟨10.1038/tpj.2015.24⟩ |
| ISSN: | 1473-1150 1470-269X |
| Popis: | International audience; Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/Fc epsilon RI pathway, such as galectin-3, a beta-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (PHis substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/Fc epsilon RI pathway in this pathology. |
| Databáze: | OpenAIRE |
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