Publicly Funded Oral Chronic Hepatitis B Treatment Patterns in Ontario over 16 Years: An Ecologic Study
| Autor: | Tara Gomes, Harry L.A. Janssen, Sandra R. Knowles, Mina Tadrous, David N. Juurlink, Diana Martins, Muhammad Mamdani, Mayur Brahmania |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Financing Government Cross-sectional study MEDLINE Pharmaceutical Science Administration Oral Pharmacy medicine.disease_cause Antiviral Agents Drug Costs Reimbursement Mechanisms 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Chronic hepatitis Internal medicine medicine Humans 030212 general & internal medicine Tenofovir health care economics and organizations Reimbursement Hepatitis B virus Ontario business.industry 030503 health policy & services Health Policy virus diseases Ecological study Hepatitis B medicine.disease digestive system diseases Cross-Sectional Studies Observational study 0305 other medical science business |
| Zdroj: | Journal of managed carespecialty pharmacy. 24(5) |
| ISSN: | 2376-1032 |
| Popis: | Reimbursement for the use of hepatitis B virus (HBV) treatments has not been previously reported for public payers.To describe the number of users and total cost of HBV treatments over the last 16 years among residents of Ontario, Canada, who were covered by the public drug program.We conducted a repeated cross-sectional study for HBV treatments reimbursed by the public drug program in Ontario from January 1, 2000, to December 31, 2015. We projected total spending to 2020 based on current utilization trends.HBV drug users per year increased 30-fold, from 132 users in 2000 to 4,035 users in 2015. Total spending on HBV treatments increased 150-fold, from $136,368 annually in 2000 to $21.0 million in 2015. The spending on HBV agents is projected to increase by 65%, with an estimated drug cost of $34.6 million by 2020.Although not reimbursed as first-line therapy, tenofovir disoproxil fumarate has become the most commonly reimbursed HBV treatment and was associated with an increase in HBV treatment use and total spending. Results of this study found that rapid growth of HBV treatments led to a sustained increase in spending for public payers in Ontario.This study was funded by grants from the Ontario Ministry of Health and Long-Term Care (MOHLTC) and Ontario Strategy for Patient-Orientated Research (SPOR) Support Unit, which is supported by the Canadian Institutes of Health Research and the Province of Ontario. This study was also supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research institute sponsored by the Ontario MOHLTC. The opinions, results, and conclusions reported in this article are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions and statements expressed herein are those of the authors and not necessarily those of CIHI. Mamdani has received honoraria from Boehringer Ingelheim, Pfizer, Bristol-Myers Squibb, and Bayer. Janssen has received research support, consulting, and/or speaking fees from Gilead, Roche, Merck, AbbVie, Bristol-Myers Squibb, Arbutus, Janssen, and MedImmune. No other authors have any conflicts of interest to declare. |
| Databáze: | OpenAIRE |
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