New Triterpene Glycosides from the Stems of Anomospermum grandifolium
| ISSN: | 1520-6025 0163-3864 |
|---|---|
| DOI: | 10.1021/np030283j |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac762e3641642897de606493b563175c https://doi.org/10.1021/np030283j |
| Přírůstkové číslo: | edsair.doi.dedup.....ac762e3641642897de606493b563175c |
| Autor: | Aurelia Tubaro, Cosimo Pizza, Sonia Piacente, M. Cinco, Alberto Plaza |
| Rok vydání: | 2003 |
| Předmět: |
Staphylococcus aureus
Antifungal Agents Stereochemistry Saponin Pharmaceutical Science Biology Pharmacognosy Menispermaceae Analytical Chemistry chemistry.chemical_compound Glucoside Triterpene Candida albicans Peru Drug Discovery Enterococcus faecalis Escherichia coli Petroleum ether Glycosides Nuclear Magnetic Resonance Biomolecular Antibacterial agent Pharmacology chemistry.chemical_classification Plants Medicinal Molecular Structure Plant Stems Organic Chemistry Dammarane Glycoside Stereoisomerism Triterpenes Complementary and alternative medicine chemistry Pseudomonas aeruginosa Molecular Medicine Ampicillin |
| Zdroj: | Journal of Natural Products. 66:1606-1610 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np030283j |
| Popis: | Two new dammarane saponins identified as jujubogenin 3-O-alpha-l-arabinofuranosyl(1-->2)-[beta-d-glucopyranosyl(1-->6) beta-d-glucopyranosyl(1-->3)]-alpha-l-arabinopyranoside (2) and jujubogenin 3-O-alpha-l-arabinofuranosyl(1-->2)-[6-O-[3-hydroxy-3-methylglutaryl]-beta-d-glucopyranosyl(1-->3)]-alpha-l-arabinopyranoside (3) and a new lupane saponin, 3beta-hydroxylup-20(29)-en-27,28-dioic acid 28-O-beta-d-glucopyranosyl(1-->2)-[beta-d-xylopyranosyl(1-->3)]-beta-d-xylopyranosyl(1-->2)-beta-d-glucopyranoside ester (5), along with the known jujubogenin 3-O-alpha-l-arabinofuranosyl(1-->2)-[beta-d-glucopyranosyl(1-->3)]-alpha-l-arabinopyranoside (1) and 3beta-hydroxylup-20(29)-ene-27,28-dioic acid (4), were isolated from the methanol extract of the stems of Anomospermum grandifolium. The structures of the new compounds were established by spectral analysis. Antimicrobial activity screening of compounds 1-3 revealed antifungal properties against C. albicans ATCC 3153 for compounds 2 and 3. The antibacterial and antifungal activities of the petroleum ether, chloroform, and methanol extracts of A. grandifolium stems were also evaluated. |
| Databáze: | OpenAIRE |
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